scholarly journals Juvenile Idiopathic Arthritis With Epstein-Barr Virus-Associated Smooth Muscle Tumor in a 6-Year-Old Girl: A Rare Case Report

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhijuan Kang ◽  
Juan Xu ◽  
Zhihui Li

Herein, we reported a rare case of Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) combined with juvenile idiopathic arthritis (JIA) in a 6-year old girl without HIV, organ transplantation, or congenital immunodeficiency. The patient suffered from pain in the bilateral hip joints, which drastically affected her physical activity. Consequently, she was diagnosed with JIA (September 2019). She was given methotrexate and methylprednisolone pills via oral route and a subcutaneous injection of Recombinant Human Tumor Necrosis Factor-α Receptor II;lgG Fc Fusion Protein for 4 weeks that successfully relieved the pain. In May 2020, the pain reoccurred and was accompanied by occasional headaches. After extensive pathological examination, the patient was diagnosed with EBV-SMT. The imaging examinations after admission showed multiple lesions in the skull, lungs, and vertebral body. Biopsy of the L2 vertebral body was then performed to clarify the diagnosis. Finally, the in-situ hybridization of the tumor of the lumbar vertebrae suggested a non-HIV/transplantation-related EBV-SMT. Consequently, the patient received surgery without chemotherapy and radiotherapy, after which her conditions improved.

2009 ◽  
Vol 133 (8) ◽  
pp. 1238-1241
Author(s):  
Le Yu ◽  
Anthony J. Aldave ◽  
Ben J. Glasgow

Abstract Epstein-Barr virus infection has been linked to the development of smooth muscle tumors in immunocompromised patients with organ transplants and acquired immunodeficiency syndrome. A 52-year-old female recipient of a renal transplant presented with enlarging masses of the left iris. Incisional biopsy of the mass revealed a smooth muscle tumor of the iris. Epstein-Barr virus infection was confirmed by in situ hybridization for Epstein-Barr virus–encoded, small RNA in tumor cells. Eight months after total iridectomy the patient was free of disease. Although the prognosis and classification of Epstein-Barr virus–associated smooth muscle tumors are controversial, mortalities caused by these tumors are rare.


2014 ◽  
Vol 109 ◽  
pp. S355
Author(s):  
Sricharitha Krishnamoorthy ◽  
Arup Maitra ◽  
Jennifer Bolyard ◽  
Zuoliang Xiao

1996 ◽  
Vol 46 (8) ◽  
pp. 601-604 ◽  
Author(s):  
Yoshito Sadahira ◽  
Takuya Moriya ◽  
Teruo Shirabe ◽  
Tsuyoshi Matsuno ◽  
Toshiaki Manabe

2004 ◽  
Vol 7 (2) ◽  
pp. 198-203 ◽  
Author(s):  
Shimareet Kumar ◽  
Mariarita Santi ◽  
Gilbert Vezina ◽  
Tena Rosser ◽  
Roma S. Chandra ◽  
...  

We describe the clinicopathologic features of an Epstein-Barr virus (EBV)-associated smooth muscle tumor arising in the basal ganglia of a 10-year-old human immunodeficiency virus (HIV)-positive child. Only a few cases of intracranial smooth muscle tumors are reported in the literature and virtually all of these have been extra-axial, involving the dura or sinuses in HIV+ adults. Our case underscores the need to include an EBV-associated smooth muscle tumor in the differential diagnosis when evaluating intracranial mass lesions in immunodeficient children.


1996 ◽  
Vol 20 (11) ◽  
pp. 1418-1425 ◽  
Author(s):  
Brigitte Le Bail ◽  
Delphine Morel ◽  
Patrick Mérel ◽  
François Comeau ◽  
Jean-Philippe Merlio ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document