scholarly journals AMPK-α1 or AMPK-α2 Deletion in Smooth Muscles Does Not Affect the Hypoxic Ventilatory Response or Systemic Arterial Blood Pressure Regulation During Hypoxia

2018 ◽  
Vol 9 ◽  
Author(s):  
Sandy MacMillan ◽  
A. Mark Evans
2020 ◽  
Vol 129 (6) ◽  
pp. 1310-1323
Author(s):  
Jennifer L. Magnusson ◽  
Craig A. Emter ◽  
Kevin J. Cummings

The role of serotonin in arterial blood pressure (ABP) regulation across states of vigilance is unknown. We hypothesized that adult rats devoid of CNS serotonin (TPH2−/−) have low ABP in wakefulness and NREM sleep, when serotonin neurons are active. However, TPH2−/− rats experience higher ABP than TPH2+/+ rats in wakefulness and REM only, a phenotype present only in older males and not females. CNS serotonin may be critical for preventing high ABP in males with aging.


2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Ludmila Lima Silveira ◽  
Elaine Fernanda Silva ◽  
Rúbia Nara Silva ◽  
Daniel A Rosa ◽  
Gustavo Rodrigues Pedrino

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