scholarly journals Low Frequency Electromagnetic Fields Might Increase the Effect of Enamel Matrix Derivative on Periodontal Tissues

2021 ◽  
Vol 11 (22) ◽  
pp. 10758
Author(s):  
Stefano Guizzardi ◽  
Giuseppe Pedrazzi ◽  
Carlo Galli
Keyword(s):  
Electromagnetic Fields ◽  
Primary Cilia ◽  
Periodontal Regeneration ◽  
Surgical Techniques ◽  
Low Frequency ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Periodontal Tissues ◽  
Osteoblast Activity ◽  
Matrix Derivative

Periodontal regeneration is a complex goal, which is commonly pursued with a combination of surgical techniques, biomaterials, and bioactive compounds. One such compound is enamel matrix derivative (EMD), a medical substance that is extracted from porcine tooth germs and which contains several protein fractions with BMP- and TGF-β-like action. Activation of TGF-β signaling is required for EMD activity on cells and tissues, and a growing body of evidence indicates that EMD largely relies on this pathway. As low frequency electromagnetic fields (EMFs) have long been investigated as a tool to promote bone formation and osteoblast activity, and because recent studies have reported that the effects of EMFs on cells require primary cilia, by modulating the presence of membrane-bound receptors (e.g., for BMP) or signal mediators, it can be hypothesized that the application of EMFs may increase cell sensitivity to EMD: as TGFBR receptors have also been identified on primary cilia, EMFs could make cells more responsive to EMD by inducing the display of a higher number of receptors on the cellular membrane.

Function of Amelogenins in Periodontal Regeneration Induced by Enamel Matrix Derivative

2011 ◽  
Vol 53 (3) ◽  
pp. 267-274 ◽  
Author(s):  
Yorimasa Ogata ◽  
Hideki Takai ◽  
Youhei Nakayama ◽  
Makoto Fukae
Keyword(s):  
Periodontal Regeneration ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Matrix Derivative

scholarly journals Two-stage approach for class II mandibular furcation defect with insufficient keratinized mucosa: a case report with 3 years’ follow-up

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110445
Author(s):  
Hiroyuki Saida ◽  
Shunsuke Fukuba ◽  
Takahiko Shiba ◽  
Keiji Komatsu ◽  
Takanori Iwata ◽  
...  
Keyword(s):  
Case Report ◽  
Periodontal Regeneration ◽  
Gingival Recession ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Two Stage ◽  
Probing Depth ◽  
Keratinized Mucosa ◽  
Depth Reduction ◽  
Matrix Derivative

Periodontal regenerative treatment is useful for intrabony defects and furcation involvement, but is difficult when there is insufficient keratinized mucosa to cover and maintain the regenerative material, particularly in the mandibular molar region. We report the case of a 27-year-old woman who underwent a two-stage surgical approach for a class II furcation defect with gingival recession and insufficient keratinized mucosal width (KMW) and vestibular depth at the mandibular left first molar. We first improved the KMW and keratinized mucosal thickness using an epithelial embossed connective tissue graft with enamel matrix derivative, and then focused on periodontal regeneration at the furcation defect using an enamel matrix derivative and a bovine-derived xenograft. Probing depth reduction, clinical attachment gain, horizontal probing depth reduction, KMW gain, and gingival recession reduction were observed 3 years postoperatively. This case report suggests that this novel staged approach may be effective for treating furcation defects with insufficient keratinized mucosa, thus providing useful insights into periodontal regeneration therapy.

scholarly journals The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 3045
Author(s):  
Alice Alberti ◽  
Luca Francetti ◽  
Silvio Taschieri ◽  
Stefano Corbella
Keyword(s):  
Clinical Trials ◽  
Bone Regeneration ◽  
Randomized Clinical Trials ◽  
Periodontal Regeneration ◽  
Case Series ◽  
Titanium Implants ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Implant Placement ◽  
Matrix Derivative

Enamel matrix derivative (EMD) has been successfully used for periodontal regeneration in intrabony defects. Recently, its use for peri-implant bone regeneration has also been hypothesized. The aim of this paper is to review preclinical and clinical studies investigating the use of EMD in correspondence with titanium implants, alone or as an adjunct to other biomaterials. Clinical trials and case series with more than five cases were included. Seven in vitro studies evaluated the effect of EMD, placed on titanium surfaces: An increase in proliferation and viability of osteoblasts was observed in all but two studies. An increase in TGF-β1 and osteocalcin production, alkaline phosphatase activity, and angiogenesis was also reported. Nine animal studies investigated the use of EMD at implant placement or for bone regeneration of peri-implant bone defects, and some of them reported a significant increase in bone formation or bone-to-implant contact. In four of eleven clinical trials on humans, EMD was successfully used at implant placement. The other seven evaluated the use of EMD in protocols for the treatment of peri-implantitis. In conclusion, the results of EMD seem promising, but further randomized clinical trials are needed to evaluate its efficacy.

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