scholarly journals Mechanisms of Stem Cell Therapy in Spinal Cord Injuries

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2676
Author(s):  
Munehisa Shinozaki ◽  
Narihito Nagoshi ◽  
Masaya Nakamura ◽  
Hideyuki Okano
Keyword(s):  
Spinal Cord ◽  
Stem Cell ◽  
Cell Therapy ◽  
Precision Medicine ◽  
Stem Cell Therapy ◽  
Spinal Cord Injuries ◽  
Pathological Condition ◽  
Chronic Phase ◽  
Cord Injury ◽  
Different Types

Every year, 0.93 million people worldwide suffer from spinal cord injury (SCI) with irretrievable sequelae. Rehabilitation, currently the only available treatment, does not restore damaged tissues; therefore, the functional recovery of patients remains limited. The pathophysiology of spinal cord injuries is heterogeneous, implying that potential therapeutic targets differ depending on the time of injury onset, the degree of injury, or the spinal level of injury. In recent years, despite a significant number of clinical trials based on various types of stem cells, these aspects of injury have not been effectively considered, resulting in difficult outcomes of trials. In a specialty such as cancerology, precision medicine based on a patient’s characteristics has brought indisputable therapeutic advances. The objective of the present review is to promote the development of precision medicine in the field of SCI. Here, we first describe the multifaceted pathophysiology of SCI, with the temporal changes after injury, the characteristics of the chronic phase, and the subtypes of complete injury. We then detail the appropriate targets and related mechanisms of the different types of stem cell therapy for each pathological condition. Finally, we highlight the great potential of stem cell therapy in cervical SCI.

scholarly journals Mesenteric Neural Stem Cell for Chronic Spinal Cord Injury: A Literature Review

2021 ◽  
Vol 9 (F) ◽  
pp. 310-317
Author(s):  
Tjokorda Gde Bagus Mahadewa ◽  
Putu Eka Mardhika ◽  
Steven Awyono ◽  
Made Bhuwana Putra ◽  
Glen Sandi Saapang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cell Therapy ◽  
Neural Stem Cell ◽  
Stem Cell Therapy ◽  
Chronic Phase ◽  
Low Risk ◽  
Current Evidence ◽  
Cord Injury

Spinal cord injury (SCI) is a common and potentially life-threatening condition with no established treatment to treat the primary injury. Mesenteric neural stem cell (NSC) therapy is a promising stem cell therapy to treat primary SCI in the chronic phase. We aimed to review the literature narratively to describe current evidence regarding mesenteric NSC in SCI. Primary SCI refers to tissue damage that occurs at the time of trauma that leads to the death of neuronal cells. In chronic SCI, the ability of neuronal regeneration is compromised by the development of gliotic scar. NSC is a stem cell therapy that targeted SCI in the chronic phase. Enteric NSC is one of the sources of NSC, and autologous gut harvesting in the appendix using endoscopic surgery provides a more straightforward and low-risk procedure. Intramedullary transplantation of stem cell with ultrasound guiding is administration technique which offers long-term regeneration. Mesenteric NSC is a promising stem cell therapy to treat chronic SCI with low risk and easier procedure to isolate cells compared to other NSC sources.

Mesenchymal stem cell therapy improves erectile dysfunction in experimental spinal cord injury

2019 ◽  
Vol 32 (3) ◽  
pp. 308-316 ◽  
Author(s):  
Ömercan Albayrak ◽  
Tarık Emre Şener ◽  
Mehmet Erşahin ◽  
Suna Özbaş-Turan ◽  
Ceyda Ekentok ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Erectile Dysfunction ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Mesenchymal Stem Cell Therapy ◽  
Experimental Spinal Cord Injury ◽  
Cord Injury

Autologous Mesenchymal Stem Cell Therapy for Spinal Cord Injury: Long Term Safety and Clinical Efficacy

2011 ◽  
Vol 3 (1) ◽  
pp. 100-106
Author(s):  
Hala Gabr ◽  
Osama Ghannam ◽  
Mohamed Reda Awad ◽  
Klaus von Wild ◽  
Wael Abo El-Kheir ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Clinical Efficacy ◽  
Stem Cell Therapy ◽  
Mesenchymal Stem Cell Therapy ◽  
Cord Injury

Stem cell therapy for spinal cord injury

2008 ◽  
Vol 5 (1) ◽  
pp. 7-10
Author(s):  
Khalil Isaac Mathai ◽  
Sasivadanan ◽  
S Sudumbraker ◽  
PK Sahoo
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cord Injury

scholarly journals Molecular Imaging in Stem Cell Therapy for Spinal Cord Injury

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Fahuan Song ◽  
Mei Tian ◽  
Hong Zhang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Molecular Imaging ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cell Biology ◽  
Cell Trafficking ◽  
Imaging Technology ◽  
Cord Injury

Spinal cord injury (SCI) is a serious disease of the center nervous system (CNS). It is a devastating injury with sudden loss of motor, sensory, and autonomic function distal to the level of trauma and produces great personal and societal costs. Currently, there are no remarkable effective therapies for the treatment of SCI. Compared to traditional treatment methods, stem cell transplantation therapy holds potential for repair and functional plasticity after SCI. However, the mechanism of stem cell therapy for SCI remains largely unknown and obscure partly due to the lack of efficient stem cell trafficking methods. Molecular imaging technology including positron emission tomography (PET), magnetic resonance imaging (MRI), optical imaging (i.e., bioluminescence imaging (BLI)) gives the hope to complete the knowledge concerning basic stem cell biology survival, migration, differentiation, and integration in real time when transplanted into damaged spinal cord. In this paper, we mainly review the molecular imaging technology in stem cell therapy for SCI.

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