Practical and Asymmetric Synthesis of Apremilast Using Ellman’s Sulfinamide as a Chiral Auxiliary
Herein, we described a new protocol for the asymmetric synthesis of apremilast using tert-butanesulfinamide as a chiral auxiliary. This synthetic route consisted of four steps starting from the commercially available 3-hydroxy-4-methoxybenzaldehyde, and apremilast was accordingly obtained in an overall 56% yield and with 95.5% ee.
2013 ◽
Vol 46
(11)
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pp. 2635-2644
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Keyword(s):
2008 ◽
Vol 2008
(35)
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pp. 5915-5921
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1985 ◽
Vol 26
(26)
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pp. 3095-3098
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Keyword(s):
2013 ◽
Vol 54
(41)
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pp. 5555-5557
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