Optimization of Two Steps in Scale-Up Synthesis of Nannocystin A
Keyword(s):
Scale Up
◽
We have accomplished a 10-step (longest linear) total synthesis of nannocystin A on a four hundred milligram scale. The previously reported Kobayashi vinylogous Mukaiyama aldol reaction to connect C4 and C5 was unreproducible during the scaling up process. A more convenient and cost-efficient Keck asymmetric vinylogous aldol reaction was employed to improve this transformation.
2015 ◽
Vol 13
(33)
◽
pp. 8906-8911
◽
2009 ◽
Vol 15
(17)
◽
pp. 4394-4401
◽
2013 ◽
Vol 52
(35)
◽
pp. 9097-9108
◽
Keyword(s):
1989 ◽
Vol 54
(26)
◽
pp. 6016-6018
◽
2014 ◽
Vol 10
◽
pp. 2421-2427
◽
Keyword(s):
Keyword(s):