scholarly journals The Outcomes of Enamel Matrix Derivative on Periodontal Regeneration under Diabetic Conditions

Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1071
Author(s):  
Laura Elena Narita ◽  
Alexandru Mester ◽  
Florin Onisor ◽  
Simion Bran ◽  
Maria Ioana Onicas ◽  
...  
Keyword(s):  
Animal Studies ◽  
Case Reports ◽  
Periodontal Regeneration ◽  
Diabetic Rats ◽  
Enamel Matrix Derivative ◽  
Regenerative Therapy ◽  
Enamel Matrix ◽  
Inclusion Criteria ◽  
Infrabony Defects ◽  
Matrix Derivative

Background and Objectives: Enamel matrix derivative (EMD) is a biomaterial used for periodontal regenerative therapy due to its properties of stimulating cementum development and bone synthesis. Diabetes is a chronic condition that affects healing and predisposes to infection. The aim of this review was to evaluate the current studies available on the application and results of EMD for periodontal regenerative therapy under diabetic conditions. Materials and Methods: Five databases (PubMed, ResearchGate, Scopus, Web of Science and Google Scholar) were searched for relevant articles, using specific keywords in different combinations. The inclusion criteria were clinical trials, case reports, case studies, and animal studies published in English, where periodontal treatment for bone defects includes EMD, and it is performed under diabetic conditions. Results: Of the 310 articles resulted in search, five studies published between 2012 and 2020 met the inclusion criteria and were selected for the current review. In human studies, the use of EMD in infrabony defects showed favorable results at follow-up. In animal studies, periodontal regeneration was reduced in diabetic rats. Conclusions: EMD might promote bone healing when used under diabetic conditions for the regenerative periodontal therapy. Due to limited number of studies, more data are required to sustain the effects of EMD therapy in diabetic settings.

Function of Amelogenins in Periodontal Regeneration Induced by Enamel Matrix Derivative

2011 ◽  
Vol 53 (3) ◽  
pp. 267-274 ◽  
Author(s):  
Yorimasa Ogata ◽  
Hideki Takai ◽  
Youhei Nakayama ◽  
Makoto Fukae
Keyword(s):  
Periodontal Regeneration ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Matrix Derivative

scholarly journals Low Frequency Electromagnetic Fields Might Increase the Effect of Enamel Matrix Derivative on Periodontal Tissues

2021 ◽  
Vol 11 (22) ◽  
pp. 10758
Author(s):  
Stefano Guizzardi ◽  
Giuseppe Pedrazzi ◽  
Carlo Galli
Keyword(s):  
Electromagnetic Fields ◽  
Primary Cilia ◽  
Periodontal Regeneration ◽  
Surgical Techniques ◽  
Low Frequency ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Periodontal Tissues ◽  
Osteoblast Activity ◽  
Matrix Derivative

Periodontal regeneration is a complex goal, which is commonly pursued with a combination of surgical techniques, biomaterials, and bioactive compounds. One such compound is enamel matrix derivative (EMD), a medical substance that is extracted from porcine tooth germs and which contains several protein fractions with BMP- and TGF-β-like action. Activation of TGF-β signaling is required for EMD activity on cells and tissues, and a growing body of evidence indicates that EMD largely relies on this pathway. As low frequency electromagnetic fields (EMFs) have long been investigated as a tool to promote bone formation and osteoblast activity, and because recent studies have reported that the effects of EMFs on cells require primary cilia, by modulating the presence of membrane-bound receptors (e.g., for BMP) or signal mediators, it can be hypothesized that the application of EMFs may increase cell sensitivity to EMD: as TGFBR receptors have also been identified on primary cilia, EMFs could make cells more responsive to EMD by inducing the display of a higher number of receptors on the cellular membrane.

scholarly journals Two-stage approach for class II mandibular furcation defect with insufficient keratinized mucosa: a case report with 3 years’ follow-up

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110445
Author(s):  
Hiroyuki Saida ◽  
Shunsuke Fukuba ◽  
Takahiko Shiba ◽  
Keiji Komatsu ◽  
Takanori Iwata ◽  
...  
Keyword(s):  
Case Report ◽  
Periodontal Regeneration ◽  
Gingival Recession ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Two Stage ◽  
Probing Depth ◽  
Keratinized Mucosa ◽  
Depth Reduction ◽  
Matrix Derivative

Periodontal regenerative treatment is useful for intrabony defects and furcation involvement, but is difficult when there is insufficient keratinized mucosa to cover and maintain the regenerative material, particularly in the mandibular molar region. We report the case of a 27-year-old woman who underwent a two-stage surgical approach for a class II furcation defect with gingival recession and insufficient keratinized mucosal width (KMW) and vestibular depth at the mandibular left first molar. We first improved the KMW and keratinized mucosal thickness using an epithelial embossed connective tissue graft with enamel matrix derivative, and then focused on periodontal regeneration at the furcation defect using an enamel matrix derivative and a bovine-derived xenograft. Probing depth reduction, clinical attachment gain, horizontal probing depth reduction, KMW gain, and gingival recession reduction were observed 3 years postoperatively. This case report suggests that this novel staged approach may be effective for treating furcation defects with insufficient keratinized mucosa, thus providing useful insights into periodontal regeneration therapy.

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