scholarly journals A Soxhlet Extract of Gongronema latifolium Retains Moderate Blood Glucose Lowering Effect and Produces Structural Recovery in the Pancreas of STZ-Induced Diabetic Rats

2016 ◽  
Vol 4 (2) ◽  
pp. 9 ◽  
Author(s):  
Bassel Al-Hindi ◽  
Nor Yusoff ◽  
Item Atangwho ◽  
Mariam Ahmad ◽  
Mohd Asmawi ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Diabetic Rats ◽  
Glucose Lowering ◽  
Lowering Effect ◽  
Structural Recovery ◽  
Glucose Lowering Effect ◽  
Gongronema Latifolium

scholarly journals Aspirin potentiates blood glucose lowering effect of glimepiride-pioglitazone combination in streptozotocin-induced diabetic rats

2014 ◽  
Vol 46 (5) ◽  
pp. 562 ◽  
Author(s):  
Suvajit Das ◽  
Chiranjib Bagchi ◽  
SantanuKumar Tripathi ◽  
Soumita Bag
Keyword(s):  
Blood Glucose ◽  
Diabetic Rats ◽  
Glucose Lowering ◽  
Lowering Effect ◽  
Glucose Lowering Effect

scholarly journals Glucose lowering effect of Zornia gibbosa Span extracts in diabetic rats

2018 ◽  
Author(s):  
Mallikarjuna Rao Talluri ◽  
Rajananda Swamy Tadi ◽  
Ganga Rao Battu ◽  
Zubair Mohammad
Keyword(s):  
Diabetic Rats ◽  
Glucose Lowering ◽  
Lowering Effect ◽  
Glucose Lowering Effect

Biochemical relevance of Cr(III) complexes of isoniazid: synthesis, characterization, DFT, antibacterial screening, antioxidant activity and glucose-lowering effect in STZ-induced diabetic rats

2019 ◽  
Vol 72 (4) ◽  
pp. 664-689 ◽  
Author(s):  
Satyendra N. Shukla ◽  
Pratiksha Gaur ◽  
Sangeeta Jhariya ◽  
Bhaskar Chaurasia ◽  
Preeti Vaidya ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Diabetic Rats ◽  
Glucose Lowering ◽  
Lowering Effect ◽  
Antibacterial Screening ◽  
Glucose Lowering Effect

scholarly journals Leptin contributes to the beneficial effects of insulin treatment in streptozotocin-diabetic male mice

2018 ◽  
Vol 315 (6) ◽  
pp. E1264-E1273
Author(s):  
Ursula H. Neumann ◽  
Michelle M. Kwon ◽  
Robert K. Baker ◽  
Timothy J. Kieffer
Keyword(s):  
Blood Glucose ◽  
Insulin Therapy ◽  
Daily Injection ◽  
Diabetic Mice ◽  
Glucose Lowering ◽  
Beneficial Effects ◽  
Glucose Levels ◽  
Lowering Effect ◽  
Blood Glucose Levels ◽  
Glucose Lowering Effect

It was long thought that the only hormone capable of reversing the catabolic consequences of diabetes was insulin. However, various studies have demonstrated that the adipocyte-derived hormone leptin can robustly lower blood glucose levels in rodent models of insulin-deficient diabetes. In addition, it has been suggested that some of the metabolic manifestations of insulin-deficient diabetes are due to hypoleptinemia as opposed to hypoinsulinemia. Because insulin therapy increases leptin levels, we sought to investigate the contribution of leptin to the beneficial effects of insulin therapy. To do this, we tested insulin therapy in streptozotocin (STZ) diabetic mice that were either on an ob/ ob background or that were given a leptin antagonist to determine if blocking leptin action would blunt the glucose-lowering effects of insulin therapy. We found that STZ diabetic ob/ ob mice have a diminished blood glucose-lowering effect in response to insulin therapy compared with STZ diabetic controls and exhibited more severe weight loss post-STZ injection. In addition, STZ diabetic mice administered a leptin antagonist through daily injection or plasmid expression respond less robustly to insulin therapy as assessed by both fasting blood glucose levels and blood glucose levels during an oral glucose tolerance test. However, leptin antagonism did not prevent the insulin-induced reduction in β-hydroxybutyrate and triglyceride levels. Therefore, we conclude that elevated leptin levels can contribute to the glucose-lowering effect of insulin therapy in insulin-deficient diabetes.

Miglitol may have a blood glucose lowering effect unrelated to inhibition of alpha-glucosidase

1987 ◽  
Vol 31 (6) ◽  
pp. 723-724 ◽  
Author(s):  
P. H. Joubert ◽  
G. N. Foukaridis ◽  
M. L. Bopape
Keyword(s):  
Blood Glucose ◽  
Glucose Lowering ◽  
Lowering Effect ◽  
Glucose Lowering Effect ◽  
Alpha Glucosidase

scholarly journals Plasma Glucose-Lowering Effect of Tramadol in Streptozotocin-Induced Diabetic Rats

Diabetes ◽  
2001 ◽  
Vol 50 (12) ◽  
pp. 2815-2821 ◽  
Author(s):  
J.-T. Cheng ◽  
I-M. Liu ◽  
T.-C. Chi ◽  
T.-F. Tzeng ◽  
F.-H. Lu ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Diabetic Rats ◽  
Glucose Lowering ◽  
Lowering Effect ◽  
Glucose Lowering Effect
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