Novel Pyrazolo[3,4-d]pyrimidine Derivatives as Potential Antitumor Agents: Exploratory Synthesis, Preliminary Structure-Activity Relationships, and in Vitro Biological Evaluation

Structure Activity ◽

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116019 ◽

2021 ◽

Vol 33 ◽

pp. 116019

Author(s):

Ikumi Kuriwaki ◽

Minoru Kameda ◽

Kazuhiko Iikubo ◽

Hiroyuki Hisamichi ◽

Yuichiro Kawamoto ◽

...

Keyword(s):

Systemic Exposure ◽

Pyrimidine Derivatives ◽

Structure Activity ◽

Orally Active

ChemInform Abstract: Potential Antitumor Agents. Part 62. Structure-Activity Relationships for Tricyclic Compounds Related to the Colon Tumor Active Drug 9-Oxo- 9H-xanthene-4-acetic Acid.

ChemInform ◽

10.1002/chin.199138211 ◽

2010 ◽

Vol 22 (38) ◽

pp. no-no

Author(s):

G. W. REWCASTLE ◽

G. J. ATWELL ◽

B. D. PALMER ◽

P. D. W. BOYD ◽

B. C. BAGULEY ◽

...

Keyword(s):

Acetic Acid ◽

Active Drug ◽

Antitumor Agents ◽

Colon Tumor ◽

Structure Activity ◽

Tricyclic Compounds ◽

Potential antitumor agents. 63. Structure-activity relationships for side-chain analogs of the colon 38 active agent 9-oxo-9H-xanthene-4-acetic acid

Journal of Medicinal Chemistry ◽

10.1021/jm00113a027 ◽

1991 ◽

Vol 34 (9) ◽

pp. 2864-2870 ◽

Cited By ~ 41

Author(s):

Gordon W. Rewcastle ◽

Graham J. Atwell ◽

Bruce C. Baguley ◽

Maruta Boyd ◽

Lindy L. Thomsen ◽

...

Keyword(s):

Acetic Acid ◽

Antitumor Agents ◽

Active Agent ◽

Side Chain ◽

Structure Activity ◽

Synthesis and structure–activity relationships of harmine derivatives as potential antitumor agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2012.11.045 ◽

2013 ◽

Vol 60 ◽

pp. 135-143 ◽

Cited By ~ 44

Author(s):

Rihui Cao ◽

Wenxi Fan ◽

Liang Guo ◽

Qin Ma ◽

Guoxian Zhang ◽

...

Keyword(s):

Antitumor Agents ◽

Structure Activity ◽

ChemInform Abstract: POTENTIAL ANTITUMOR AGENTS. 42. STRUCTURE-ACTIVITY RELATIONSHIPS FOR ACRIDINE-SUBSTITUTED DIMETHYL PHOSPHORAMIDATE DERIVATIVES OF 9-ANILINOACRIDINE

Chemischer Informationsdienst ◽

10.1002/chin.198503228 ◽

1985 ◽

Vol 16 (3) ◽

Author(s):

G. W. REWCASTLE ◽

G. J. ATWELL ◽

B. C. BAGULEY ◽

W. A. DENNY

Keyword(s):

Antitumor Agents ◽

Structure Activity ◽

Derivatives Of ◽

Synthesis, Biological Evaluation, and Quantitative Structure−Activity Relationship Analysis of New Schiff Bases of Hydroxysemicarbazide as Potential Antitumor Agents†

Journal of Medicinal Chemistry ◽

10.1021/jm010252q ◽

2002 ◽

Vol 45 (2) ◽

pp. 410-419 ◽

Cited By ~ 185

Author(s):

Shijun Ren ◽

Rubin Wang ◽

Kenichi Komatsu ◽

Patricia Bonaz-Krause ◽

Yegor Zyrianov ◽

...

Keyword(s):

Schiff Bases ◽

Antitumor Agents ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Quantitative Structure ◽

Relationship Analysis ◽

Structure Activity ◽

Design, synthesis, and structure–activity relationships of novel 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2013.08.019 ◽

2013 ◽

Vol 69 ◽

pp. 77-89 ◽

Cited By ~ 44

Author(s):

Qidong Tang ◽

Yanfang Zhao ◽

Xinming Du ◽

Lian'e Chong ◽

Ping Gong ◽

...

Keyword(s):

Antitumor Agents ◽

Design Synthesis ◽

Structure Activity ◽

Structure–activity relationships in glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans as DNA binding and potential antitumor agents

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.01.014 ◽

2011 ◽

Vol 19 (5) ◽

pp. 1779-1789 ◽

Cited By ~ 10

Author(s):

Wei Shi ◽

Todd L. Lowary

Keyword(s):

Dna Binding ◽

Antitumor Agents ◽

Structure Activity ◽

ChemInform Abstract: POTENTIAL ANTITUMOR AGENTS. 29. QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS S FOR THE ANTILEUKEMIC BISQUATERNARY AMMONIUM HETEROCYCLES

Chemischer Informationsdienst ◽

10.1002/chin.197925233 ◽

1979 ◽

Vol 10 (25) ◽

Author(s):

W. A. DENNY ◽

G. J. ATWELL ◽

B. C. BAGULEY ◽

B. F. CAIN

Keyword(s):

Antitumor Agents ◽

Quantitative Structure ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm700956r ◽

2008 ◽

Vol 51 (3) ◽

pp. 487-501 ◽

Cited By ~ 56

Author(s):

Ermes Vanotti ◽

Raffaella Amici ◽

Alberto Bargiotti ◽

Jens Berthelsen ◽

Roberta Bosotti ◽

...

Keyword(s):

Kinase Inhibitors ◽

Antitumor Agents ◽

Structure Activity ◽

Cdc7 Kinase ◽