Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Structure Activity ◽

Orally Active

Studies on the synthesis, in vitro antitumor activity of 4H-benzo[h]chromene, 7H-benzo[h]chromene[2,3-d]pyrimidine derivatives and structure–activity relationships of the 2-,3- and 2,3-positions

Medicinal Chemistry Research ◽

10.1007/s00044-013-0904-x ◽

2014 ◽

Vol 23 (6) ◽

pp. 3187-3199 ◽

Cited By ~ 26

Author(s):

Ahmed M. El-Agrody ◽

Ahmed M. Fouda ◽

Al-Anood M. Al-Dies

Keyword(s):

Antitumor Activity ◽

Pyrimidine Derivatives ◽

Novel Pyrazolo[3,4-d]pyrimidine Derivatives as Potential Antitumor Agents: Exploratory Synthesis, Preliminary Structure-Activity Relationships, and in Vitro Biological Evaluation

Molecules ◽

10.3390/molecules161210685 ◽

2011 ◽

Vol 16 (12) ◽

pp. 10685-10694 ◽

Cited By ~ 24

Author(s):

Hai-Yun He ◽

Jin-Ni Zhao ◽

Ruo Jia ◽

Ying-Lan Zhao ◽

Sheng-Yong Yang ◽

...

Keyword(s):

Antitumor Agents ◽

Biological Evaluation ◽

Pyrimidine Derivatives ◽

Structure Activity ◽

Potential Antitumor

Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure–activity relationships (SARs) as antibacterial agent

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2010.08.010 ◽

2010 ◽

Vol 45 (11) ◽

pp. 5031-5038 ◽

Cited By ~ 21

Author(s):

Mazaahir Kidwai ◽

Roona Poddar ◽

Saurav Bhardwaj ◽

Satendra Singh ◽

Pratibha Mehta Luthra

Keyword(s):

Antibacterial Agent ◽

In Vitro Study ◽

Vitro Study ◽

Structure-activity relationships of steroids in inducing germinal vesicle breakdown of Atlantic croaker oocytes in vitro

General and Comparative Endocrinology ◽

10.1016/0016-6480(88)90259-6 ◽

1988 ◽

Vol 71 (2) ◽

pp. 307-317 ◽

Cited By ~ 72

Author(s):

John M. Trant ◽

Peter Thomas

Keyword(s):

Germinal Vesicle ◽

Atlantic Croaker ◽

Germinal Vesicle Breakdown ◽

Novel Hepatitis C virus replicon inhibitors: Synthesis and structure–activity relationships of fused pyrimidine derivatives

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.01.096 ◽

2012 ◽

Vol 22 (6) ◽

pp. 2212-2215 ◽

Cited By ~ 26

Author(s):

A. Chris Krueger ◽

Darold L. Madigan ◽

David W. Beno ◽

David A. Betebenner ◽

Robert Carrick ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Pyrimidine Derivatives ◽

Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum11Abbreviations: CDK, cyclin-dependent kinase; CDK1, cyclin-dependent kinase 1; and PfPK, Plasmodium falciparum protein kinase.

Biochemical Pharmacology ◽

10.1016/s0006-2952(01)00644-x ◽

2001 ◽

Vol 62 (3) ◽

pp. 341-348 ◽

Cited By ~ 37

Author(s):

Leonie Harmse ◽

Robyn van Zyl ◽

Nathanael Gray ◽

Peter Schultz ◽

Sophie Leclerc ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Protein Kinase ◽

In Vitro Growth ◽

Cyclin Dependent Kinase ◽

Purine Derivatives ◽

Inhibitory Effects ◽

Structure Activity ◽

Falciparum Protein

Advances in Experimental Medicine and Biology - Biological Reactive Intermediates IV ◽

Structure-Activity Relationships of Acrylate Esters: Reactivity Towards Glutathione and Hydrolysis by Carboxylesterase in Vitro

10.1007/978-1-4684-5877-0_42 ◽

1991 ◽

pp. 333-335 ◽

Cited By ~ 5

Author(s):

T. J. McCarthy ◽

G. Witz

Keyword(s):

Structure Activity ◽

Acrylate Esters

Structure-activity relationships of cysteine esters and their effects on thiol levels in rat lung in vitro

Biochemical Pharmacology ◽

10.1016/0006-2952(93)90301-c ◽

1993 ◽

Vol 45 (8) ◽

pp. 1605-1612 ◽

Cited By ~ 17

Author(s):

M.J. Hobbs ◽

M. Butterworth ◽

G.M. Cohen ◽

D.G. Upshall

Keyword(s):

Rat Lung ◽

Design of 2,5-Dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and Structure−Activity Relationships of a Series of Potent and Orally Active Corticotropin-Releasing Factor Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm040058e ◽

2004 ◽

Vol 47 (19) ◽

pp. 4787-4798 ◽

Cited By ~ 91

Author(s):

Chen ◽

Keith M. Wilcoxen ◽

Charles Q. Huang ◽

Yun-Feng Xie ◽

James R. McCarthy ◽

...

Keyword(s):

Corticotropin Releasing Factor ◽

Receptor Antagonists ◽

Structure Activity ◽

Orally Active

Structure-activity relationships of tetramethylpiperidine-substituted phenazines against Mycobacterium leprae in vitro.

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.33.11.2004 ◽

1989 ◽

Vol 33 (11) ◽

pp. 2004-2005 ◽

Cited By ~ 15

Author(s):

S G Franzblau ◽

K E White ◽

J F O'Sullivan

Keyword(s):

Mycobacterium Leprae ◽