Faculty Opinions recommendation of Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils.

2001 ◽  
Author(s):  
James Goldman
Keyword(s):  
Transgenic Mice ◽  
Neurofibrillary Tangles

P4-334: Combination of memantine and donepezil reverses cognitive deficits in transgenic mice with both amyloid-beta plaques and neurofibrillary tangles

2009 ◽  
Vol 5 (4S_Part_17) ◽  
pp. e29-e29 ◽  
Author(s):  
Frank M. LaFerla ◽  
Hilda Martinez-Coria ◽  
Kim N. Green ◽  
Pradeep K. Banerjee
Keyword(s):  
Transgenic Mice ◽  
Amyloid Beta ◽  
Cognitive Deficits ◽  
Neurofibrillary Tangles

Lithium Treatment Arrests the Development of Neurofibrillary Tangles in Mutant Tau Transgenic Mice with Advanced Neurofibrillary Pathology

2010 ◽  
Vol 19 (2) ◽  
pp. 705-719 ◽  
Author(s):  
Karelle Leroy ◽  
Kunie Ando ◽  
Céline Héraud ◽  
Zehra Yilmaz ◽  
Michèle Authelet ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Neurofibrillary Tangles ◽  
Lithium Treatment ◽  
Neurofibrillary Pathology

scholarly journals Early Axonopathy Preceding Neurofibrillary Tangles in Mutant Tau Transgenic Mice

2007 ◽  
Vol 171 (3) ◽  
pp. 976-992 ◽  
Author(s):  
Karelle Leroy ◽  
Alexis Bretteville ◽  
Katharina Schindowski ◽  
Emmanuel Gilissen ◽  
Michèle Authelet ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Neurofibrillary Tangles

Ultrastructural Pathology of Neurofibrillary Tangles in Transgenic Mice Carrying Mutant (P301l) Human Tau Gene

2000 ◽  
Vol 6 (S2) ◽  
pp. 584-585
Author(s):  
W.-L. Lin ◽  
J. Lewis ◽  
A.R. Corral ◽  
D.W. Dickson ◽  
M. Hutton
Keyword(s):  
Transgenic Mice ◽  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Frontotemporal Dementia ◽  
Neurofibrillary Tangles ◽  
Autosomal Dominant ◽  
Chromosome 17 ◽  
Exon 1 ◽  
Normal Human ◽  
Transgenic Construct

Tau is a microtubule-associated protein that promotes polymerization and stabilization of microtubules. It is the major component of fibrillary neuronal and glial inclusions in Alzheimer's disease (AD) and the tauopathies. An autosomal dominant familial tauopathy, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), has been shown to be caused by pathogenic tau mutations. Neuropathologic features of FTDP-17 are filamentous tau aggregates in neurons and glia. Previous transgenic mice carrying the normal human tau gene developed motor neuron disease and had dystrophic axons, but no neurofibrillary tangles (NFT). In this report we describe ultrastructural features of NFT in transgenic mice carrying a mutant human tau gene. The mice were generated with a tau cDNA containing exon 1, 4, 5, 7, 9, 10, 11-13, intron 13 and exon 14, driven by the mouse prion promoter (MoPrP) and containing the most common FTDP-17 mutation, P301L. The transgenic construct was generated by ligating the P301L tau cDNA with the mouse prion promoter.

P2-078 Neurofibrillary tangles and cell death in transgenic mice expressing non-mutant human isoforms of TAU

2004 ◽  
Vol 25 ◽  
pp. S246
Author(s):  
Cathy A. Andorfer ◽  
Christopher M. Acker ◽  
Yvonee Kress ◽  
Karen Duff ◽  
Peter Davies
Keyword(s):  
Cell Death ◽  
Transgenic Mice ◽  
Neurofibrillary Tangles ◽  
Human Isoforms
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