Faculty Opinions recommendation of Folding properties of the nucleotide exchange factor GrpE from Thermus thermophilus: GrpE is a thermosensor that mediates heat shock response.

2001 ◽  
Author(s):  
Franz Schmid
Keyword(s):  
Heat Shock ◽  
Heat Shock Response ◽  
Thermus Thermophilus ◽  
Nucleotide Exchange ◽  
Exchange Factor ◽  
Nucleotide Exchange Factor ◽  
Shock Response

Regulation of ATPase and chaperone cycle of DnaK from Thermus thermophilus by the nucleotide exchange factor GrpE

2001 ◽  
Vol 305 (5) ◽  
pp. 1173-1183 ◽  
Author(s):  
Yvonne Groemping ◽  
Dagmar Klostermeier ◽  
Christian Herrmann ◽  
Thomas Veit ◽  
Ralf Seidel ◽  
...  
Keyword(s):  
Thermus Thermophilus ◽  
Nucleotide Exchange ◽  
Exchange Factor ◽  
Nucleotide Exchange Factor

scholarly journals Roles of the nucleotide exchange factor and chaperone Hsp110 in cellular proteostasis and diseases of protein misfolding

2018 ◽  
Vol 399 (10) ◽  
pp. 1215-1221 ◽  
Author(s):  
Unekwu M. Yakubu ◽  
Kevin A. Morano
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Molecular Chaperones ◽  
Protein Misfolding ◽  
Recent Progress ◽  
Cellular Protein ◽  
Protein Homeostasis ◽  
Nucleotide Exchange ◽  
Exchange Factor ◽  
Nucleotide Exchange Factor

Abstract Cellular protein homeostasis (proteostasis) is maintained by a broad network of proteins involved in synthesis, folding, triage, repair and degradation. Chief among these are molecular chaperones and their cofactors that act as powerful protein remodelers. The growing realization that many human pathologies are fundamentally diseases of protein misfolding (proteopathies) has generated interest in understanding how the proteostasis network impacts onset and progression of these diseases. In this minireview, we highlight recent progress in understanding the enigmatic Hsp110 class of heat shock protein that acts as both a potent nucleotide exchange factor to regulate activity of the foldase Hsp70, and as a passive chaperone capable of recognizing and binding cellular substrates on its own, and its integration into the proteostasis network.

scholarly journals Reversible Thermal Transition in GrpE, the Nucleotide Exchange Factor of the DnaK Heat-Shock System

2000 ◽  
Vol 276 (9) ◽  
pp. 6098-6104 ◽  
Author(s):  
John P. A. Grimshaw ◽  
Ilian Jelesarov ◽  
Hans-Joachim Schönfeld ◽  
Philipp Christen
Keyword(s):  
Heat Shock ◽  
Thermal Transition ◽  
Nucleotide Exchange ◽  
Exchange Factor ◽  
Nucleotide Exchange Factor ◽  
Shock System
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