Faculty Opinions recommendation of Inhibitors of COP-mediated transport and cholera toxin action inhibit simian virus 40 infection.

2002 ◽  
Author(s):  
Karin Romisch
Keyword(s):  
Cholera Toxin ◽  
Simian Virus 40 ◽  
Simian Virus

scholarly journals Inhibitors of COP-mediated Transport and Cholera Toxin Action Inhibit Simian Virus 40 Infection

2002 ◽  
Vol 13 (5) ◽  
pp. 1750-1764 ◽  
Author(s):  
Ayanthi A. Richards ◽  
Espen Stang ◽  
Rainer Pepperkok ◽  
Robert G. Parton
Keyword(s):  
Endoplasmic Reticulum ◽  
Cholera Toxin ◽  
Brefeldin A ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
Potent Inhibition ◽  
Successful Infection ◽  
Sv40 Infection ◽  
Dependent Transport ◽  
Infectious Entry

Simian virus 40 (SV40) is a nonenveloped virus that has been shown to pass from surface caveolae to the endoplasmic reticulum in an apparently novel infectious entry pathway. We now show that the initial entry step is blocked by brefeldin A and by incubation at 20°C. Subsequent to the entry step, the virus reaches a domain of the rough endoplasmic reticulum by an unknown pathway. This intracellular trafficking pathway is also brefeldin A sensitive. Infection is strongly inhibited by expression of GTP-restricted ADP-ribosylation factor 1 (Arf1) and Sar1 mutants and by microinjection of antibodies to βCOP. In addition, we demonstrate a potent inhibition of SV40 infection by the dipeptideN-benzoyl-oxycarbonyl-Gly-Phe-amide, which also inhibits late events in cholera toxin action. Our results identify novel inhibitors of SV40 infection and show that SV40 requires COPI- and COPII-dependent transport steps for successful infection.

Chemical modification of simian virus 40 DNA by reaction with a water-soluble carbodiimide.

1976 ◽  
Vol 18 (1) ◽  
pp. 205-210 ◽  
Author(s):  
J Lebowitz ◽  
C G Garon ◽  
M C Chen ◽  
N P Salzman
Keyword(s):  
Chemical Modification ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
Water Soluble

Mapping simian virus 40 mutants by construction of partial heterozygotes.

1975 ◽  
Vol 16 (3) ◽  
pp. 754-757 ◽  
Author(s):  
N Mantel ◽  
H W Boyer ◽  
H M Goodman
Keyword(s):  
Simian Virus 40 ◽  
Simian Virus
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