Faculty Opinions recommendation of Alpha-7 nicotinic receptor expression by two distinct cell types in the dorsal raphe nucleus and locus coeruleus of rat.

2002 ◽  
Author(s):  
Gary Aston-Jones
Keyword(s):  
Locus Coeruleus ◽  
Nicotinic Receptor ◽  
Dorsal Raphe Nucleus ◽  
Cell Types ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Receptor Expression ◽  
Distinct Cell ◽  
Alpha 7 ◽  
Dorsal Raphé

Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways

2013 ◽  
Vol 67 ◽  
pp. 379-394 ◽  
Author(s):  
Audrey Francisco Biagioni ◽  
Renato Leonardo de Freitas ◽  
Juliana Almeida da Silva ◽  
Rithiele Cristina de Oliveira ◽  
Ricardo de Oliveira ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Dorsomedial Hypothalamus ◽  
Defensive Behaviours ◽  
Dorsal Raphé

Attenuation of morphine analgesia in rats with lesions of the locus coeruleus and dorsal raphe nucleus

1977 ◽  
Vol 42 (1) ◽  
pp. 53-62 ◽  
Author(s):  
Masashi Sasa ◽  
Katsunori Munekiyo ◽  
Yoshitsugu Osumi ◽  
Shuji Takaori
Keyword(s):  
Locus Coeruleus ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Morphine Analgesia ◽  
Dorsal Raphé

scholarly journals Target-specific modulation of the descending prefrontal cortex inputs to the dorsal raphe nucleus by cannabinoids

2016 ◽  
Vol 113 (19) ◽  
pp. 5429-5434 ◽  
Author(s):  
Sean D. Geddes ◽  
Saleha Assadzada ◽  
David Lemelin ◽  
Alexandra Sokolovski ◽  
Richard Bergeron ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dorsal Raphe Nucleus ◽  
Cell Types ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Wide Range ◽  
Stress Processing ◽  
Large Ensembles ◽  
Distributed Regulation ◽  
Dorsal Raphé

Serotonin (5-HT) neurons located in the raphe nuclei modulate a wide range of behaviors by means of an expansive innervation pattern. In turn, the raphe receives a vast array of synaptic inputs, and a remaining challenge lies in understanding how these individual inputs are organized, processed, and modulated in this nucleus to contribute ultimately to the core coding features of 5-HT neurons. The details of the long-range, top-down control exerted by the medial prefrontal cortex (mPFC) in the dorsal raphe nucleus (DRN) are of particular interest, in part, because of its purported role in stress processing and mood regulation. Here, we found that the mPFC provides a direct monosynaptic, glutamatergic drive to both DRN 5-HT and GABA neurons and that this architecture was conducive to a robust feed-forward inhibition. Remarkably, activation of cannabinoid (CB) receptors differentially modulated the mPFC inputs onto these cell types in the DRN, in effect regulating the synaptic excitatory/inhibitory balance governing the excitability of 5-HT neurons. Thus, the CB system dynamically reconfigures the processing features of the DRN, a mood-related circuit believed to provide a concerted and distributed regulation of the excitability of large ensembles of brain networks.

Inhibitory Mechanisms in the Dorsal Raphe Nucleus and Locus Coeruleus During Sleep

2019 ◽  
pp. 195-211
Author(s):  
Pierre-Hervé Luppi ◽  
Christelle Peyron ◽  
Claire Rampon ◽  
Damien Gervasoni ◽  
Bruno Barbagli ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Inhibitory Mechanisms ◽  
Dorsal Raphé

Hypocretin in locus coeruleus and dorsal raphe nucleus mediates inescapable footshock stimulation (IFS)-induced REM sleep alteration

SLEEP ◽  
2021 ◽  
Author(s):  
Yun Lo ◽  
Pei-Lu Yi ◽  
Yi-Tse Hsiao ◽  
Fang-Chia Chang
Keyword(s):  
Locus Coeruleus ◽  
Rem Sleep ◽  
Energy Homeostasis ◽  
Dorsal Raphe Nucleus ◽  
Nrem Sleep ◽  
Dorsal Raphe ◽  
Wave Activity ◽  
Raphe Nucleus ◽  
Sleep Disruption ◽  
Dorsal Raphé

Abstract Hypocretin (hcrt) is a stress-reacting neuropeptide mediating arousal and energy homeostasis. An inescapable footshock stimulation (IFS) could initiate the hcrt release from the lateral hypothalamus (LHA) and suppresses rapid eye movement (REM) sleep in rodents. However, the effects of the IFS-induced hcrts on REM-off nuclei, the locus coeruleus (LC) and dorsal raphe nucleus (DRN), remained unclear. We hypothesized that the hcrt projections from the LHA to LC or DRN mediate IFS-induced sleep disruption. Our results demonstrated that the IFS increased hcrt expression and the neuronal activities in the LHA, hypothalamus, brainstem, thalamus, and amygdala. Suppressions of REM sleep and slow wave activity during non-REM (NREM) sleep caused by the high expression of hcrts were blocked when a non-specific and dual hcrt receptor antagonist was administered into the LC or DRN. Furthermore, the IFS also caused an elevated innate anxiety, but was limitedly influenced by the hcrt antagonist. This result suggests that the increased hcrt concentrations in the LC and DRN mediate stress-induced sleep disruptions and might partially involve IFS-induced anxiety.

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