Faculty Opinions recommendation of Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists.

Author(s):  
Lennart Brodin
Neuron ◽  
2003 ◽  
Vol 37 (3) ◽  
pp. 433-447 ◽  
Author(s):  
Mala Murthy ◽  
Dan Garza ◽  
Richard H. Scheller ◽  
Thomas L. Schwarz

2018 ◽  
Author(s):  
Eva P. Karasmanis ◽  
Cat-Thi Phan ◽  
Dimitrios Angelis ◽  
Ilona A. Kesisova ◽  
Casper C. Hoogenraad ◽  
...  

2018 ◽  
Vol 46 (4) ◽  
pp. 518-524 ◽  
Author(s):  
Eva P. Karasmanis ◽  
Cat-Thi Phan ◽  
Dimitrios Angelis ◽  
Ilona A. Kesisova ◽  
Casper C. Hoogenraad ◽  
...  

2007 ◽  
Vol 99 (6) ◽  
pp. 333-342 ◽  
Author(s):  
Michael R. Schmidt ◽  
Volker Haucke

2015 ◽  
Vol 12 (102) ◽  
pp. 20141119 ◽  
Author(s):  
Tianshu Liu ◽  
Pankaj Singh ◽  
James T. Jenkins ◽  
Anand Jagota ◽  
Maria Bykhovskaia ◽  
...  

Neurotransmitter release from neuronal terminals is governed by synaptic vesicle fusion. Vesicles filled with transmitters are docked at the neuronal membrane by means of the SNARE machinery. After a series of events leading up to the fusion pore formation, neurotransmitters are released into the synaptic cleft. In this paper, we study the mechanics of the docking process. A continuum model is used to determine the deformation of a spherical vesicle and a plasma membrane, under the influence of SNARE-machinery forces and electrostatic repulsion. Our analysis provides information on the variation of in-plane stress in the membranes, which is known to affect fusion. Also, a simple model is proposed to study hemifusion.


2000 ◽  
Vol 20 (23) ◽  
pp. 8551-8565 ◽  
Author(s):  
Xiaolu Wang ◽  
Friedrich W. Herberg ◽  
Michael M. Laue ◽  
Christiane Wüllner ◽  
Bin Hu ◽  
...  

2018 ◽  
Vol 46 (2) ◽  
pp. 204-218.e7 ◽  
Author(s):  
Eva P. Karasmanis ◽  
Cat-Thi Phan ◽  
Dimitrios Angelis ◽  
Ilona A. Kesisova ◽  
Casper C. Hoogenraad ◽  
...  

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