Faculty Opinions recommendation of Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells.

2003 ◽  
Author(s):  
Valeri Vasioukhin
Keyword(s):  
Human Cells ◽  
Aurora A ◽  
Lim Protein

scholarly journals Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells

Cell ◽  
2003 ◽  
Vol 114 (5) ◽  
pp. 585-598 ◽  
Author(s):  
Toru Hirota ◽  
Naoko Kunitoku ◽  
Takashi Sasayama ◽  
Tomotoshi Marumoto ◽  
Dongwei Zhang ◽  
...  
Keyword(s):  
Human Cells ◽  
Aurora A ◽  
Lim Protein

scholarly journals A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells

Development ◽  
2010 ◽  
Vol 137 (23) ◽  
pp. e2308-e2308
Author(s):  
Y. Abe ◽  
Y. Abe ◽  
E. Okumura ◽  
T. Hosoya ◽  
T. Hirota ◽  
...  
Keyword(s):  
Aurora Kinase ◽  
Human Cells ◽  
Aurora B ◽  
Aurora A

scholarly journals Cdk1 Activity Is Required for Mitotic Activation of Aurora A during G2/M Transition of Human Cells

2010 ◽  
Vol 285 (28) ◽  
pp. 21849-21857 ◽  
Author(s):  
Robert D. Van Horn ◽  
Shaoyou Chu ◽  
Li Fan ◽  
Tinggui Yin ◽  
Jian Du ◽  
...  
Keyword(s):  
Human Cells ◽  
Aurora A

scholarly journals A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells

2010 ◽  
Vol 123 (22) ◽  
pp. 3978-3988 ◽  
Author(s):  
Y. Abe ◽  
E. Okumura ◽  
T. Hosoya ◽  
T. Hirota ◽  
T. Kishimoto
Keyword(s):  
Aurora Kinase ◽  
Human Cells ◽  
Aurora B ◽  
Aurora A

scholarly journals VX-680 Inhibits Aurora A and Aurora B Kinase Activity in Human Cells

Cell Cycle ◽  
2007 ◽  
Vol 6 (22) ◽  
pp. 2846-2854 ◽  
Author(s):  
Rebecca K. Tyler ◽  
Natalia Shpiro ◽  
Rodolfo Marquez ◽  
Patrick A. Eyers
Keyword(s):  
Kinase Activity ◽  
Human Cells ◽  
Aurora B ◽  
Aurora A ◽  
Aurora B Kinase

scholarly journals Aurora A kinase regulates proper spindle positioning inC. elegansand in human cells

2016 ◽  
Vol 129 (15) ◽  
pp. 3015-3025 ◽  
Author(s):  
Sachin Kotak ◽  
Katayon Afshar ◽  
Coralie Busso ◽  
Pierre Gönczy
Keyword(s):  
Human Cells ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Spindle Positioning

scholarly journals Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A

2008 ◽  
Vol 182 (2) ◽  
pp. 289-300 ◽  
Author(s):  
Alexander W. Bird ◽  
Anthony A. Hyman
Keyword(s):  
Bacterial Artificial Chromosome ◽  
Artificial Chromosome ◽  
Spindle Pole ◽  
Human Cells ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Mitotic Spindles ◽  
Independent Function ◽  
Microtubule Nucleation ◽  
Cell Mitosis

To assemble mitotic spindles, cells nucleate microtubules from a variety of sources including chromosomes and centrosomes. We know little about how the regulation of microtubule nucleation contributes to spindle bipolarity and spindle size. The Aurora A kinase activator TPX2 is required for microtubule nucleation from chromosomes as well as for spindle bipolarity. We use bacterial artificial chromosome–based recombineering to introduce point mutants that block the interaction between TPX2 and Aurora A into human cells. TPX2 mutants have very short spindles but, surprisingly, are still bipolar and segregate chromosomes. Examination of microtubule nucleation during spindle assembly shows that microtubules fail to nucleate from chromosomes. Thus, chromosome nucleation is not essential for bipolarity during human cell mitosis when centrosomes are present. Rather, chromosome nucleation is involved in spindle pole separation and setting spindle length. A second Aurora A–independent function of TPX2 is required to bipolarize spindles.

scholarly journals The Aurora-A/TPX2 Axis Directs Spindle Orientation in Adherent Human Cells by Regulating NuMA and Microtubule Stability

2020 ◽  
Author(s):  
Federica Polverino ◽  
Francesco D. Naso ◽  
Italia A. Asteriti ◽  
Valentina Palmerini ◽  
Divya Singh ◽  
...  
Keyword(s):  
Human Cells ◽  
Spindle Orientation ◽  
Aurora A ◽  
Microtubule Stability
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