Faculty Opinions recommendation of Crystal structure of the malaria vaccine candidate apical membrane antigen 1.

2005 ◽  
Author(s):  
Sylvie Doublié
Keyword(s):  
Crystal Structure ◽  
Malaria Vaccine ◽  
Vaccine Candidate ◽  
Apical Membrane ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen ◽  
Malaria Vaccine Candidate

scholarly journals Apical Membrane Antigen 1, a Major Malaria Vaccine Candidate, Mediates the Close Attachment of Invasive Merozoites to Host Red Blood Cells

2004 ◽  
Vol 72 (1) ◽  
pp. 154-158 ◽  
Author(s):  
G. H. Mitchell ◽  
A. W. Thomas ◽  
G. Margos ◽  
A. R. Dluzewski ◽  
L. H. Bannister
Keyword(s):  
Malaria Vaccine ◽  
Vaccine Candidate ◽  
Apical Membrane ◽  
Plasmodium Knowlesi ◽  
Red Cells ◽  
Red Cell ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen ◽  
Malaria Vaccine Candidate ◽  
Candidate Molecule

ABSTRACT Apical membrane antigen 1 (AMA-1) of Plasmodium merozoites is established as a candidate molecule for inclusion in a human malaria vaccine and is strongly conserved in the genus. We have investigated its function in merozoite invasion by incubating Plasmodium knowlesi merozoites with red cells in the presence of a previously described rat monoclonal antibody (MAb R31C2) raised against an invasion-inhibitory epitope of P. knowlesi AMA-1 and then fixing the material for ultrastructural analysis. We have found that the random, initial, long-range (12 nm) contact between merozoites and red cells occurs normally in the presence of the antibody, showing that AMA-1 plays no part in this stage of attachment. Instead, inhibited merozoites fail to reorientate, so they do not bring their apices to bear on the red cell surface and do not make close junctional apical contact. We conclude that AMA-1 may be directly responsible for reorientation or that the molecule may initiate the junctional contact, which is then presumably dependent on Duffy binding proteins for its completion.

scholarly journals Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen-1 (AMA-1) Administered in Adjuvant System AS01B or AS02A

PLoS ONE ◽  
2009 ◽  
Vol 4 (4) ◽  
pp. e5254 ◽  
Author(s):  
Michele D. Spring ◽  
James F. Cummings ◽  
Christian F. Ockenhouse ◽  
Sheetij Dutta ◽  
Randall Reidler ◽  
...  
Keyword(s):  
Malaria Vaccine ◽  
Vaccine Candidate ◽  
Apical Membrane ◽  
Phase 1 ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen ◽  
Adjuvant System ◽  
Malaria Vaccine Candidate

Apical membrane antigen 1: a malaria vaccine candidate in review

2008 ◽  
Vol 24 (2) ◽  
pp. 74-84 ◽  
Author(s):  
Edmond J. Remarque ◽  
Bart W. Faber ◽  
Clemens H.M. Kocken ◽  
Alan W. Thomas
Keyword(s):  
Malaria Vaccine ◽  
Vaccine Candidate ◽  
Apical Membrane ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen ◽  
Malaria Vaccine Candidate

scholarly journals Fine Mapping of an Epitope Recognized by an Invasion-inhibitory Monoclonal Antibody on the Malaria Vaccine Candidate Apical Membrane Antigen 1

2006 ◽  
Vol 282 (10) ◽  
pp. 7431-7441 ◽  
Author(s):  
Christine R. Collins ◽  
Chrislaine Withers-Martinez ◽  
Graham A. Bentley ◽  
Adrian H. Batchelor ◽  
Alan W. Thomas ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Fine Mapping ◽  
Malaria Vaccine ◽  
Vaccine Candidate ◽  
Apical Membrane ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen ◽  
Malaria Vaccine Candidate
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