Faculty Opinions recommendation of Interface of physical and emotional stress regulation through the endogenous opioid system and mu-opioid receptors.

2015 ◽  
Author(s):  
Rita Valentino
Keyword(s):  
Emotional Stress ◽  
Opioid Receptors ◽  
Opioid System ◽  
Mu Opioid Receptors ◽  
Endogenous Opioid System ◽  
Endogenous Opioid ◽  
Stress Regulation ◽  
Mu Opioid

Interface of physical and emotional stress regulation through the endogenous opioid system and μ-opioid receptors

2005 ◽  
Vol 29 (8) ◽  
pp. 1264-1280 ◽  
Author(s):  
Saulo C. Ribeiro ◽  
Susan E. Kennedy ◽  
Yolanda R. Smith ◽  
Christian S. Stohler ◽  
Jon-Kar Zubieta
Keyword(s):  
Emotional Stress ◽  
Opioid Receptors ◽  
Opioid System ◽  
Endogenous Opioid System ◽  
Endogenous Opioid ◽  
Stress Regulation ◽  
Μ Opioid Receptors

scholarly journals The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and κ and μ Opioid Receptors are Associated with Interleukin-6

2020 ◽  
Author(s):  
Shatha Rouf Moustafa ◽  
Khalid F. Al-Rawi ◽  
Arafat Hussein Al-Dujaili ◽  
Thitiporn Supasitthumrong ◽  
Hussein Kadhem Al-Hakeim ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Opioid System ◽  
Response To Treatment ◽  
Treatment Resistant ◽  
Endogenous Opioid System ◽  
Endogenous Opioid ◽  
Mu Opioid ◽  
Beta Endorphin ◽  
Neurocognitive Impairments ◽  
Thought Disorders

Background: Activation of the immune-inflammatory response system (IRS) and the compensatory immune-regulatory system (CIRS) play a key role in SCZ and treatment resistant SCZ. There are only few data on immune and endogenous opioid system (EOS) interactions in SCZ and treatment resistant SCZ.Aim of the study: We examined serum β-endorphin, endomorphin-2 (EM2), mu-opioid (MOR) and kappa-opioid (KOR) receptors, and interleukin (IL)-6 and IL-10 in 60 non responders to treatment (NRTT), 55 partial RTT (PRTT) and 43 normal controls.Results: Serum EM2, KOR, MOR, IL-6 and IL-10 were significantly increased in SCZ as compared with controls. β-endorphin, EM2, MOR and IL-6 were significantly higher in NRTT than in PRTT. There were significant correlations between IL-6, on the one hand, and β-endorphin, EM2, KOR, and MOR, on the other, while IL-10 was significantly correlated with MOR only. A large part of the variance in negative symptoms, psychosis, hostility, excitation, mannerism, psychomotor retardation and formal thought disorders was explained by the combined effects of EM2 and MOR with or without IL-6 while increased KOR was significantly associated with all symptom dimensions. Increased MOR, KOR, EM2 and IL-6 were also associated with neurocognitive impairments including in episodic, semantic and working memory and executive functions.Conclusion: The EOS contributes to SCZ symptomatology, neurocognitive impairments and a non-response to treatment. In SCZ, EOS peptides/receptors may exert CIRS functions, whereas increased KOR levels may contribute to the pathophysiology of SCZ and EM2 and KOR to a non-response to treatment.

Borderline personality disorder - a dysregulation of the endogenous opioid system?

2011 ◽  
Vol 26 (S2) ◽  
pp. 1008-1008
Author(s):  
B. Bandelow ◽  
C. Schmahl ◽  
P. Falkai ◽  
D. Wedekind
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Opioid Receptors ◽  
Borderline Personality ◽  
Endogenous Opioids ◽  
The Body ◽  
Opioid System ◽  
Endogenous Opioid System ◽  
Endogenous Opioid ◽  
Self Injury

The neurobiology of borderline personality disorder (BPD) remains unclear. Dysfunctions of several neurobiological systems have been discussed, including serotoninergic, dopaminergic, and other neurotransmitter systems.Here we present a theory that alterations in the sensitivity of opioid receptors or the availability of endogenous opioids constitute part of the underlying pathophysiology of BPD.1 The alarming symptoms and self-destructive behaviors of the affected patients may be explained by uncontrollable and unconscious attempts to stimulate their endogenous opioid system (EOS) and the dopaminergic reward system, regardless of the possible harmful consequences. Neurobiological findings that support this hypothesis are reviewed: Frantic efforts to avoid abandonment, frequent and risky sexual contacts, and attention-seeking behavior may be explained by attempts to make use of the rewarding effects of human attachment mediated by the EOS. Anhedonia and feelings of emptiness may be an expression of reduced activity of the EOS. Patients with BPD tend to abuse substances that target μ-opioid receptors. Self-injury, food-restriction, aggressive behavior, and sensation-seeking may be interpreted as a desperate attempt to artificially set the body to “survival mode”, in order to mobilize the last reserves of the EOS. BPD-associated symptoms, such as substance abuse, anorexia, self-injury, depersonalization, and sexual overstimulation, can be treated successfully with μ-opioid receptor antagonists.An understanding of the neurobiology of BPD may help in developing new treatments for patients with this severe disorder.

MODULATION BY CCK-B RECEPTORS OF THE ANTINOCICEPTIVE AND REWARDING PROPERTIES INDUCED BY THE ENDOGENOUS OPIOID SYSTEM

Analgesia ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 809-812
Author(s):  
O. Valverde ◽  
M.-C. Fournié-Zaluski ◽  
B. P. Roques ◽  
R. Maldonado
Keyword(s):  
Opioid System ◽  
Endogenous Opioid System ◽  
Endogenous Opioid

A Structural Feature of the Non-Peptide Ligand Interactions with Mice Mu-Opioid Receptors

2015 ◽  
Vol 10 (4) ◽  
pp. 354-360 ◽  
Author(s):  
Hamid Noori ◽  
Christian Mucksch ◽  
Herbert Urbassek
Keyword(s):  
Structural Feature ◽  
Opioid Receptors ◽  
Peptide Ligand ◽  
Mu Opioid Receptors ◽  
Mu Opioid ◽  
Ligand Interactions

scholarly journals Nicotine Effects and the Endogenous Opioid System

2014 ◽  
Vol 125 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Shiroh Kishioka ◽  
Norikazu Kiguchi ◽  
Yuka Kobayashi ◽  
Fumihiro Saika
Keyword(s):  
Opioid System ◽  
Endogenous Opioid System ◽  
Endogenous Opioid

scholarly journals Endomorphin-2 and Endomorphin-1 Promote the Extracellular Amount of Accumbal Dopamine via Nonopioid and Mu-Opioid Receptors, Respectively

2005 ◽  
Vol 31 (2) ◽  
pp. 375-383 ◽  
Author(s):  
Hiroko Okutsu ◽  
Shu Watanabe ◽  
Ichiro Takahashi ◽  
Yuri Aono ◽  
Tadashi Saigusa ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Mu Opioid Receptors ◽  
Mu Opioid
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