Faculty Opinions recommendation of Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder.

2009 ◽  
Author(s):  
Rudolf Hoehn-Saric
Keyword(s):  
Prefrontal Cortex ◽  
Anxiety Disorder ◽  
Children And Adolescents ◽  
Generalized Anxiety Disorder ◽  
Generalized Anxiety ◽  
Ventrolateral Prefrontal Cortex

Attenuated responses to emotional expressions in women with generalized anxiety disorder

2010 ◽  
Vol 41 (5) ◽  
pp. 1009-1018 ◽  
Author(s):  
M. E. Palm ◽  
R. Elliott ◽  
S. McKie ◽  
J. F. W. Deakin ◽  
I. M. Anderson
Keyword(s):  
Prefrontal Cortex ◽  
Anxiety Disorder ◽  
Anterior Cingulate Cortex ◽  
Facial Expressions ◽  
Generalized Anxiety Disorder ◽  
Recognition Task ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Generalized Anxiety ◽  
Bold Signal

BackgroundGeneralized anxiety disorder (GAD) is under-researched despite its high prevalence and large impact on the healthcare system. There is a paucity of functional magnetic resonance imaging (fMRI) studies that explore the neural correlates of emotional processing in GAD. The present study investigated the blood oxygen level dependent (BOLD) response to processing positive and negative facial emotions in patients with GAD.MethodA total of 15 female GAD patients and 16 female controls undertook an implicit face emotion task during fMRI scanning. They also performed a face emotion recognition task outside the scanner.ResultsThe only behavioural difference observed in GAD patients was less accurate detection of sad facial expressions compared with control participants. However, GAD patients showed an attenuated BOLD signal in the prefrontal cortex to fearful, sad, angry and happy facial expressions and an attenuated signal in the anterior cingulate cortex to happy and fearful facial expressions. No differences were found in amygdala response.ConclusionsIn contrast with previous research, this study found BOLD signal attenuation in the ventrolateral and medial prefrontal cortex and the anterior cingulate cortex during face emotion processing, consistent with a hypothesis of hypo-responsivity to external emotional stimuli in GAD. These decreases were in areas that have been implicated in emotion and cognition and may reflect an altered balance between internally and externally directed attentional processes.

scholarly journals The relation of worry to prefrontal cortex volume in older adults with and without generalized anxiety disorder

2009 ◽  
Vol 173 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Jan Mohlman ◽  
Rebecca B. Price ◽  
Dana A. Eldreth ◽  
Daniel Chazin ◽  
Dorie M. Glover ◽  
...  
Keyword(s):  
Older Adults ◽  
Prefrontal Cortex ◽  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Generalized Anxiety
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