Faculty Opinions recommendation of TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals.

2009 ◽  
Author(s):  
Lily Jan
Keyword(s):  
Chloride Channel ◽  
Protein Complex ◽  
Channel Activity ◽  
Calcium Dependent ◽  
Presynaptic Protein ◽  
Novel Protein

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

Science ◽  
2008 ◽  
Vol 322 (5901) ◽  
pp. 590-594 ◽  
Author(s):  
A. Caputo ◽  
E. Caci ◽  
L. Ferrera ◽  
N. Pedemonte ◽  
C. Barsanti ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Chloride Channel ◽  
Channel Activity ◽  
Calcium Dependent

scholarly journals Arrhythmia and sudden death associated with elevated cardiac chloride channel activity

2011 ◽  
Vol 15 (11) ◽  
pp. 2307-2316 ◽  
Author(s):  
L. Ye ◽  
W. Zhu ◽  
P. H. Backx ◽  
M. A. Cortez ◽  
J. Wu ◽  
...  
Keyword(s):  
Sudden Death ◽  
Chloride Channel ◽  
Channel Activity

scholarly journals Human spermatozoa possess a calcium-dependent chloride channel that may participate in the acrosomal reaction

2012 ◽  
Vol 590 (11) ◽  
pp. 2659-2675 ◽  
Author(s):  
Gerardo Orta ◽  
Gonzalo Ferreira ◽  
Omar José ◽  
Claudia L. Treviño ◽  
Carmen Beltrán ◽  
...  
Keyword(s):  
Chloride Channel ◽  
Human Spermatozoa ◽  
Calcium Dependent ◽  
Acrosomal Reaction

scholarly journals Myotubes from transgenic mdx mice expressing full-length dystrophin show normal calcium regulation.

1994 ◽  
Vol 5 (10) ◽  
pp. 1159-1167 ◽  
Author(s):  
W F Denetclaw ◽  
F W Hopf ◽  
G A Cox ◽  
J S Chamberlain ◽  
R A Steinhardt
Keyword(s):  
Single Channel ◽  
Calcium Regulation ◽  
Full Length ◽  
Mdx Mice ◽  
Free Calcium ◽  
Muscle Degeneration ◽  
Channel Activity ◽  
Mouse Muscle ◽  
Calcium Dependent ◽  
Normal Calcium

A lack of dystrophin results in muscle degeneration in Duchenne muscular dystrophy. Dystrophin-deficient human and mouse muscle cells have higher resting levels of intracellular free calcium ([Ca2+]i) and show a related increase in single-channel open probabilities of calcium leak channels. Elevated [Ca2+]i results in high levels of calcium-dependent proteolysis, which in turn increases calcium leak channel activity. This process could initiate muscle degeneration by further increasing [Ca2+]i and proteolysis in a positive feedback loop. Here, we tested the direct effect of restoration of dystrophin on [Ca2+]i and channel activity in primary myotubes from mdx mice made transgenic for full-length dystrophin. Transgenic mdx mice have been previously shown to have normal dystrophin localization and no muscle degeneration. Fura-2 calcium measurements and single-channel patch recordings showed that resting [Ca2+]i levels and open probabilities of calcium leak channels of transgenic mdx myotubes were similar to normal levels and significantly lower than mdx littermate controls (mdx) that lack dystrophin. Thus, restoration of normal calcium regulation in transgenic mdx mice may underlie the resulting absence of degeneration.

A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits

1998 ◽  
Vol 12 (6) ◽  
pp. 469-478 ◽  
Author(s):  
Michael Seeger ◽  
Regine Kraft ◽  
Katherine Ferrell ◽  
Dawadschargal Bech‐Otschir ◽  
Renate Dumdey ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Protein Complex ◽  
26S Proteasome ◽  
Proteasome Subunits ◽  
Novel Protein

Molecular cloning and characterisation of SaCLCa1, a novel protein of the chloride channel (CLC) family from the halophyte Suaeda altissima (L.) Pall

2019 ◽  
Vol 240 ◽  
pp. 152995 ◽  
Author(s):  
O.I. Nedelyaeva ◽  
A.V. Shuvalov ◽  
I.V. Karpichev ◽  
D.V. Beliaev ◽  
N.A. Myasoedov ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
Chloride Channel ◽  
Suaeda Altissima ◽  
Novel Protein

scholarly journals Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation

2019 ◽  
Vol 41 (2) ◽  
pp. 208-217 ◽  
Author(s):  
Can-zhao Liu ◽  
Fei-ya Li ◽  
Xiao-fei Lv ◽  
Ming-ming Ma ◽  
Xiang-yu Li ◽  
...  
Keyword(s):  
Chloride Channel ◽  
Channel Activity ◽  
Selective Autophagy
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