Faculty Opinions recommendation of Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells.

2011 ◽  
Author(s):  
Paul Turek
Keyword(s):  
Stem Cells ◽  
Germ Cell ◽  
Pluripotent Stem Cells ◽  
Cell Specification ◽  
Germ Cell Specification

scholarly journals Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells

2016 ◽  
Vol 39 (1) ◽  
pp. 87-103 ◽  
Author(s):  
Kenjiro Shirane ◽  
Kazuki Kurimoto ◽  
Yukihiro Yabuta ◽  
Masashi Yamaji ◽  
Junko Satoh ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Germ Cell ◽  
Pluripotent Stem Cells ◽  
Cell Specification ◽  
Germ Cell Specification

scholarly journals Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells

Cell ◽  
2011 ◽  
Vol 146 (4) ◽  
pp. 519-532 ◽  
Author(s):  
Katsuhiko Hayashi ◽  
Hiroshi Ohta ◽  
Kazuki Kurimoto ◽  
Shinya Aramaki ◽  
Mitinori Saitou
Keyword(s):  
Stem Cells ◽  
Germ Cell ◽  
Pluripotent Stem Cells ◽  
Cell Specification ◽  
Germ Cell Specification

scholarly journals Germ cell specification in mice: signaling, transcription regulation, and epigenetic consequences

Reproduction ◽  
2010 ◽  
Vol 139 (6) ◽  
pp. 931-942 ◽  
Author(s):  
Mitinori Saitou ◽  
Masashi Yamaji
Keyword(s):  
Stem Cells ◽  
Germ Cell ◽  
Transcription Regulation ◽  
Cell Fate ◽  
Pluripotent Stem Cells ◽  
Genetic Information ◽  
Cell Specification ◽  
Cellular Events ◽  
Genome Wide ◽  
Germ Cell Specification

The specification of germ cell fate in development initiates mechanisms essential for the perpetuation of genetic information across the generations. Recent studies in mice have shown that germ cell specification requires at least three key molecular/cellular events: repression of the somatic program, re-acquisition of potential pluripotency, and an ensuing genome-wide epigenetic reprogramming. Moreover, a signaling and transcriptional principle governing these processes has been identified, raising the possibility of inducing the germ cell fate precisely from pluripotent stem cells in culture. These advances will in turn serve as a basis to explore the mechanism of germ cell specification in other mammals, including humans. The recapitulation of germ cell development in humans in culture will provide unprecedented opportunities to understand the basis of the propagation of our genome, both under normal and diseased conditions.

Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification

2020 ◽  
Author(s):  
Leqian Yu ◽  
Yulei Wei ◽  
Hai-Xi Sun ◽  
Ahmed K. Mahdi ◽  
Carlos A. Pinzon Arteaga ◽  
...  
Keyword(s):  
Stem Cells ◽  
Germ Cell ◽  
Pluripotent Stem Cells ◽  
Primordial Germ Cell ◽  
Cell Specification ◽  
Germ Cell Specification
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