Faculty Opinions recommendation of Quality control in the initiation of eukaryotic DNA replication.

2012 ◽  
Author(s):  
Marcel Mechali
Keyword(s):  
Quality Control ◽  
Dna Replication ◽  
Eukaryotic Dna

scholarly journals Quality control in the initiation of eukaryotic DNA replication

2011 ◽  
Vol 366 (1584) ◽  
pp. 3545-3553 ◽  
Author(s):  
John F. X. Diffley
Keyword(s):  
Cell Cycle ◽  
Quality Control ◽  
Cell Death ◽  
Dna Replication ◽  
Genome Stability ◽  
Relative Importance ◽  
Entire Genome ◽  
Initiation Of Replication ◽  
Eukaryotic Dna ◽  
Do So

Origins of DNA replication must be regulated to ensure that the entire genome is replicated precisely once in each cell cycle. In human cells, this requires that tens of thousands of replication origins are activated exactly once per cell cycle. Failure to do so can lead to cell death or genome rearrangements such as those associated with cancer. Systems ensuring efficient initiation of replication, while also providing a robust block to re-initiation, play a crucial role in genome stability. In this review, I will discuss some of the strategies used by cells to ensure once per cell cycle replication and provide a quantitative framework to evaluate the relative importance and efficiency of individual pathways involved in this regulation.

Eukaryotic DNA replication

BioEssays ◽  
1985 ◽  
Vol 2 (4) ◽  
pp. 148-154 ◽  
Author(s):  
David T. Denhardt ◽  
Emanuel A. Faust
Keyword(s):  
Dna Replication ◽  
Eukaryotic Dna

scholarly journals DNAReplication: a database of information and resources for the eukaryotic DNA replication community

2009 ◽  
Vol 37 (Database) ◽  
pp. D837-D839 ◽  
Author(s):  
S. Cotterill ◽  
S. E. Kearsey
Keyword(s):  
Dna Replication ◽  
Eukaryotic Dna

Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork

2006 ◽  
pp. 27-68 ◽  
Author(s):  
Heinz Peter Nasheuer ◽  
Helmut Pospiech ◽  
Juhani Syväoja
Keyword(s):  
Dna Replication ◽  
Replication Fork ◽  
Eukaryotic Dna
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