Faculty Opinions recommendation of A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers.

2012 ◽  
Author(s):  
Elizabeth Mellins ◽  
Wei Jiang
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
Major Histocompatibility Complex Class ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Class Ii ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

scholarly journals CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice.

1995 ◽  
Vol 182 (4) ◽  
pp. 993-1004 ◽  
Author(s):  
S Cardell ◽  
S Tangri ◽  
S Chan ◽  
M Kronenberg ◽  
C Benoist ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
Major Histocompatibility Complex Class ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Class Ii ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Deficient Mice

Rather unexpectedly, major histocompatibility complex class II-deficient mice have a significant population of peripheral CD4+ T lymphocytes. We have investigated these cells at the population and clonal levels. CD4+ T lymphocytes from class II-deficient animals are thymically derived, appear early in ontogeny, exhibit the phenotype of resting memory cells, are potentially functional by several criteria, and have a diverse T cell receptor repertoire. They do not include substantially elevated numbers of NK1.1+ cells. Hybridomas derived after polyclonal stimulation of the CD4+ lymphocytes from class II-deficient animals include a subset with an unusual reactivity pattern, responding to splenocytes from many mouse strains including the strain of origin. Most members of this subset recognize the major histocompatibility complex class Ib molecule CD1; their heterogeneous reactivities and T cell receptor usage further suggest the involvement of peptides and/or highly variable posttranslational modifications.

T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding

2008 ◽  
Vol 45 (9) ◽  
pp. 2700-2709 ◽  
Author(s):  
David K. Cole ◽  
Steven M. Dunn ◽  
Malkit Sami ◽  
Jonathan M. Boulter ◽  
Bent K. Jakobsen ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
Major Histocompatibility Complex Class ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I–bound peptide

2005 ◽  
Vol 6 (11) ◽  
pp. 1114-1122 ◽  
Author(s):  
Fleur E Tynan ◽  
Scott R Burrows ◽  
Ashley M Buckle ◽  
Craig S Clements ◽  
Natalie A Borg ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
Major Histocompatibility Complex Class ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Receptor Recognition
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