Faculty Opinions recommendation of Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.

2013 ◽  
Author(s):  
Laurel Lenz ◽  
Rebecca Schmidt
Keyword(s):  
Cyclic Gmp ◽  
Second Messenger ◽  
Innate Immune ◽  
Immune Signaling ◽  
Innate Immune Signaling

Cyclic GMP–AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

2017 ◽  
Vol 86 (1) ◽  
pp. 541-566 ◽  
Author(s):  
Kazuki Kato ◽  
Hiroki Omura ◽  
Ryuichiro Ishitani ◽  
Osamu Nureki
Keyword(s):  
Cyclic Gmp ◽  
Second Messenger ◽  
Innate Immune ◽  
Immune Signaling ◽  
Innate Immune Signaling

scholarly journals Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

Science ◽  
2012 ◽  
Vol 339 (6121) ◽  
pp. 826-830 ◽  
Author(s):  
J. Wu ◽  
L. Sun ◽  
X. Chen ◽  
F. Du ◽  
H. Shi ◽  
...  
Keyword(s):  
Cyclic Gmp ◽  
Second Messenger ◽  
Innate Immune ◽  
Immune Signaling ◽  
Innate Immune Signaling

scholarly journals The Second Messenger Phosphatidylinositol-5-Phosphate Facilitates Antiviral Innate Immune Signaling

2013 ◽  
Vol 14 (2) ◽  
pp. 148-158 ◽  
Author(s):  
Takumi Kawasaki ◽  
Naoki Takemura ◽  
Daron M. Standley ◽  
Shizuo Akira ◽  
Taro Kawai
Keyword(s):  
Second Messenger ◽  
Innate Immune ◽  
Immune Signaling ◽  
Innate Immune Signaling

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

Science ◽  
2018 ◽  
Vol 361 (6403) ◽  
pp. 704-709 ◽  
Author(s):  
Mingjian Du ◽  
Zhijian J. Chen
Keyword(s):  
Enzyme Activity ◽  
Phase Separation ◽  
Liquid Phase ◽  
Dna Binding ◽  
Cyclic Gmp ◽  
Innate Immune ◽  
Immune Signaling ◽  
Secondary Messenger ◽  
Innate Immune Signaling

The binding of DNA to cyclic GMP–AMP synthase (cGAS) leads to the production of the secondary messenger cyclic GMP–AMP (cGAMP), which activates innate immune responses. We have shown that DNA binding to cGAS robustly induced the formation of liquidlike droplets in which cGAS was activated. The disordered and positively charged cGAS N terminus enhanced cGAS-DNA phase separation by increasing the valencies of DNA binding. Long DNA was more efficient in promoting cGAS liquid phase separation and cGAS enzyme activity than short DNA. Moreover, free zinc ions enhanced cGAS enzyme activity both in vitro and in cells by promoting cGAS-DNA phase separation. These results demonstrated that the DNA-induced phase transition of cGAS promotes cGAMP production and innate immune signaling.

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