Faculty Opinions recommendation of Spinal and supraspinal control of the direction of stepping during locomotion.

2013 ◽  
Author(s):  
Ansgar Büschges
Keyword(s):  
Supraspinal Control

Pharmacology of descending control systems

1985 ◽  
Vol 308 (1136) ◽  
pp. 375-391 ◽  
Keyword(s):  
Opioid Peptides ◽  
Indirect Evidence ◽  
Good Evidence ◽  
Convincing Evidence ◽  
Nociceptive Transmission ◽  
Supraspinal Control ◽  
Site Of Action ◽  
Nociceptive Information ◽  
Nociceptive Input ◽  
Spinal Inhibition

In the cat there is no convincing evidence that a particular compound mediates a supraspinal control of spinal transmission of nociceptive information. There is good evidence that opioid peptides are released segmentally in response to nociceptive input to the spinal cord and that this acts to inhibit motoneurons and to reduce transmission of nociceptive information to supraspinal areas. In the cat there is no evidence that stimulation at supraspinal sites producing analgesia results in a spinal release of opioid peptides. In the rat evidence for the latter has been obtained but there are no data from other species. Tonically present supraspinal inhibition of spinal transmission of nociceptive information in the cat does not involve opioid peptides. Indirect evidence favours a role for 5-hydroxytryptamine and noradrenaline in supraspinal control of spinal processing of nociceptive transmission. Peripheral antagonists of 5-HT have reduced spinal inhibition from stimulation at supraspinal sites but the site of action is unknown. Progress with noradrenaline involvement has been hindered by lack of a suitable antagonist. Although the amino acids, glycine and GABA are involved in segmental inhibition of transmission of nociceptive information, no convincing evidence has indicated their involvement in supraspinal controls.

scholarly journals A critical period in the supraspinal control of pain: opioid-dependent changes in brainstem rostroventral medulla function in preadolescence

Pain ◽  
2012 ◽  
Vol 153 (4) ◽  
pp. 775-783 ◽  
Author(s):  
Gareth J. Hathway ◽  
David Vega-Avelaira ◽  
Maria Fitzgerald
Keyword(s):  
Critical Period ◽  
Supraspinal Control

Supraspinal Control of Recurrent Inhibition during Anisometric Contractions

2019 ◽  
Vol 51 (11) ◽  
pp. 2357-2365
Author(s):  
SIMON BARRUÉ-BELOU ◽  
PHILIPPE MARQUE ◽  
JULIEN DUCLAY
Keyword(s):  
Recurrent Inhibition ◽  
Supraspinal Control

scholarly journals 70 Supraspinal control of urine storage and micturition in men – an fMRI study

2013 ◽  
Vol 12 (1) ◽  
pp. e70-e71
Author(s):  
L. Michels ◽  
J. Wöllner ◽  
F. Gregorini ◽  
M. Kurz ◽  
T.M. Kessler ◽  
...  
Keyword(s):  
Supraspinal Control ◽  
Fmri Study ◽  
Urine Storage

scholarly journals Chronic, complete cervical6–7 cord transection: distinct autonomic and cardiac deficits

2018 ◽  
Vol 124 (6) ◽  
pp. 1471-1482 ◽  
Author(s):  
Heidi L. Lujan ◽  
Anne Tonson ◽  
Robert W. Wiseman ◽  
Stephen E. DiCarlo
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Arterial Blood Pressure ◽  
Histological Examination ◽  
Hormonal Responses ◽  
Sympathetic Preganglionic Neurons ◽  
Supraspinal Control ◽  
Arterial Blood ◽  
Cord Injury ◽  
First Time

Spinal cord injury (SCI) resulting in tetraplegia is a devastating, life-changing insult causing paralysis and sensory impairment as well as distinct autonomic dysfunction that triggers compromised cardiovascular, bowel, bladder, and sexual activity. Life becomes a battle for independence as even routine bodily functions and the smallest activity of daily living become major challenges. Accordingly, there is a critical need for a chronic preclinical model of tetraplegia. This report addresses this critical need by comparing, for the first time, resting-, reflex-, and stress-induced cardiovascular, autonomic, and hormonal responses each week for 4 wk in 12 sham-operated intact rats and 12 rats with chronic, complete C6–7 spinal cord transection. Loss of supraspinal control to all sympathetic preganglionic neurons projecting to the heart and vasculature resulted in a profound bradycardia and hypotension, reduced cardiac sympathetic and parasympathetic tonus, reduced reflex- and stress-induced sympathetic responses, and reduced sympathetic support of blood pressure as well as enhanced reliance on angiotensin to maintain arterial blood pressure. Histological examination of the nucleus ambiguus and stellate ganglia supports the profound and distinct autonomic and cardiac deficits and reliance on angiotensin to maintain cardiovascular stability following chronic, complete cervical6–7 cord transection. NEW & NOTEWORTHY For the first time, resting-, reflex-, and stress-induced cardiovascular, autonomic, and hormonal responses were studied in rats with chronic, complete C6–7 cord transection. Loss of supraspinal control of all sympathetic preganglionic neurons reduced cardiac sympathetic and parasympathetic tonus, reflex and stress-induced sympathetic responses, and sympathetic support of blood pressure as well as enhanced reliance on angiotensin to maintain arterial blood pressure. Histological examination supports the distinct deficits associated with cervical cord injury.

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