Faculty Opinions recommendation of A clinical model for identifying radiosensitive tumor genotypes in non-small cell lung cancer.

2014 ◽  
Author(s):  
Minesh Mehta ◽  
Manmeet Ahluwalia
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Clinical Model

A Clinical Model to Estimate Recurrence Risk in Resected Stage I Non-Small Cell Lung Cancer

2008 ◽  
Vol 31 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Boone Goodgame ◽  
Avinash Viswanathan ◽  
C Ryan Miller ◽  
Feng Gao ◽  
Bryan Meyers ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Recurrence Risk ◽  
Small Cell ◽  
Stage I ◽  
Small Cell Lung ◽  
Clinical Model ◽  
Resected Stage

scholarly journals A Clinical Model for Identifying Radiosensitive Tumor Genotypes in Non–Small Cell Lung Cancer

2013 ◽  
Vol 19 (19) ◽  
pp. 5523-5532 ◽  
Author(s):  
Kimberly L. Johung ◽  
Xiaopan Yao ◽  
Fangyong Li ◽  
James B. Yu ◽  
Scott N. Gettinger ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Clinical Model

scholarly journals Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories

Open Biology ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 200247
Author(s):  
Robert E. Hynds ◽  
Kristopher K. Frese ◽  
David R. Pearce ◽  
Eva Grönroos ◽  
Caroline Dive ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Invasive Disease ◽  
Small Cell ◽  
Genetically Engineered ◽  
Model Systems ◽  
Small Cell Lung ◽  
Clinical Model ◽  
Metastatic Colonization

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. Although advances are being made towards earlier detection and the development of impactful targeted therapies and immunotherapies, the 5-year survival of patients with advanced disease is still below 20%. Effective cancer research relies on pre-clinical model systems that accurately reflect the evolutionary course of disease progression and mimic patient responses to therapy. Here, we review pre-clinical models, including genetically engineered mouse models and patient-derived materials, such as cell lines, primary cell cultures, explant cultures and xenografts, that are currently being used to interrogate NSCLC evolution from pre-invasive disease through locally invasive cancer to the metastatic colonization of distant organ sites.

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