Faculty Opinions recommendation of Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid.

2014 ◽  
Author(s):  
William A Muller
Keyword(s):  
Notch Signaling ◽  
Muller Glia ◽  
Müller Glia ◽  
Glia Cells ◽  
Retinal Angiogenesis

scholarly journals Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid

2014 ◽  
Vol 204 (3) ◽  
pp. 2043OIA18
Author(s):  
Jiong Hu ◽  
Rüdiger Popp ◽  
Timo Frömel ◽  
Manuel Ehling ◽  
Khader Awwad ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Muller Glia ◽  
Müller Glia ◽  
Glia Cells ◽  
Retinal Angiogenesis

scholarly journals Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid

2014 ◽  
Vol 211 (2) ◽  
pp. 281-295 ◽  
Author(s):  
Jiong Hu ◽  
Rüdiger Popp ◽  
Timo Frömel ◽  
Manuel Ehling ◽  
Khader Awwad ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Notch Signaling Pathway ◽  
Müller Cell ◽  
Muller Glia ◽  
Müller Glia ◽  
Lipid Profiling ◽  
Glia Cells ◽  
Retinal Angiogenesis ◽  
Muller Cell

Cytochrome P450 (CYP) epoxygenases generate bioactive lipid epoxides which can be further metabolized to supposedly less active diols by the soluble epoxide hydrolase (sEH). As the role of epoxides and diols in angiogenesis is unclear, we compared retinal vasculature development in wild-type and sEH−/− mice. Deletion of the sEH significantly delayed angiogenesis, tip cell, and filopodia formation, a phenomenon associated with activation of the Notch signaling pathway. In the retina, sEH was localized in Müller glia cells, and Müller cell–specific sEH deletion reproduced the sEH−/− retinal phenotype. Lipid profiling revealed that sEH deletion decreased retinal and Müller cell levels of 19,20–dihydroxydocosapentaenoic acid (DHDP), a diol of docosahexenoic acid (DHA). 19,20-DHDP suppressed endothelial Notch signaling in vitro via inhibition of the γ-secretase and the redistribution of presenilin 1 from lipid rafts. Moreover, 19,20-DHDP, but not the parent epoxide, was able to rescue the defective angiogenesis in sEH−/− mice as well as in animals lacking the Fbxw7 ubiquitin ligase, which demonstrate strong basal activity of the Notch signaling cascade. These studies demonstrate that retinal angiogenesis is regulated by a novel form of neuroretina–vascular interaction involving the sEH-dependent generation of a diol of DHA in Müller cells.

Peanut agglutinin binding glycoproteins in the chick retina: Their presence in Müller glia cells

1992 ◽  
Vol 31 (3) ◽  
pp. 532-542 ◽  
Author(s):  
C. Arregui ◽  
H. S. Barra ◽  
C. A. Landa
Keyword(s):  
Muller Glia ◽  
Müller Glia ◽  
Peanut Agglutinin ◽  
Glia Cells ◽  
Chick Retina

Glutamate Receptor Stimulation Up-Regulates Glutamate Uptake in Human Müller Glia Cells

2016 ◽  
Vol 41 (7) ◽  
pp. 1797-1805 ◽  
Author(s):  
Ana María López-Colomé ◽  
Edith López ◽  
Orquidia G. Mendez-Flores ◽  
Arturo Ortega
Keyword(s):  
Glutamate Receptor ◽  
Glutamate Uptake ◽  
Muller Glia ◽  
Müller Glia ◽  
Receptor Stimulation ◽  
Glia Cells

Proteomic profiling of primary retinal Müller glia cells reveals a shift in expression patterns upon adaptation to in vitro conditions

Glia ◽  
2003 ◽  
Vol 44 (3) ◽  
pp. 251-263 ◽  
Author(s):  
Stefanie M. Hauck ◽  
Sabine Suppmann ◽  
Marius Ueffing
Keyword(s):  
Expression Patterns ◽  
Muller Glia ◽  
Müller Glia ◽  
Proteomic Profiling ◽  
Glia Cells

scholarly journals Viability of Primary Human Pigment Epithelium Cells and Muller-Glia Cells after Intravitreal Ziv-Aflibercept and Aflibercept

2016 ◽  
Vol 236 (4) ◽  
pp. 223-227 ◽  
Author(s):  
Gabriel Costa de Andrade ◽  
Christian Wertheimer ◽  
Kirsten Eibl ◽  
Armin Wolf ◽  
Anselm Kampik ◽  
...  
Keyword(s):  
Pigment Epithelium ◽  
Muller Glia ◽  
Müller Glia ◽  
Glia Cells ◽  
Epithelium Cells

scholarly journals Adult Human Müller Glia Cells Are a Highly Efficient Source of Rod Photoreceptors

Stem Cells ◽  
2011 ◽  
Vol 29 (2) ◽  
pp. 344-356 ◽  
Author(s):  
Serena G. Giannelli ◽  
Gian Carlo Demontis ◽  
Grazia Pertile ◽  
Paolo Rama ◽  
Vania Broccoli
Keyword(s):  
Muller Glia ◽  
Müller Glia ◽  
Rod Photoreceptors ◽  
Glia Cells ◽  
Adult Human ◽  
Highly Efficient

scholarly journals Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Müller glia cells

2006 ◽  
Vol 15 (18) ◽  
pp. 2659-2672 ◽  
Author(s):  
Agnes G.S.H. van Rossum ◽  
Wendy M. Aartsen ◽  
Jan Meuleman ◽  
Jan Klooster ◽  
Anna Malysheva ◽  
...  
Keyword(s):  
Muller Glia ◽  
Müller Glia ◽  
Glia Cells ◽  
Subapical Region

scholarly journals Antiserum to lens antigens immunostains Muller glia cells in the neural retina.

1985 ◽  
Vol 82 (16) ◽  
pp. 5570-5573 ◽  
Author(s):  
A. A. Moscona ◽  
L. Fox ◽  
J. Smith ◽  
L. Degenstein
Keyword(s):  
Neural Retina ◽  
Muller Glia ◽  
Müller Glia ◽  
Glia Cells
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