Faculty Opinions recommendation of Epicutaneous immunotherapy induces gastrointestinal LAP+regulatory T cells and prevents food-induced anaphylaxis.

Author(s):  
Wesley Burks ◽  
Mike Kulis
2017 ◽  
Vol 139 (1) ◽  
pp. 189-201.e4 ◽  
Author(s):  
Leticia Tordesillas ◽  
Lucie Mondoulet ◽  
Ana Belen Blazquez ◽  
Pierre-Henri Benhamou ◽  
Hugh A. Sampson ◽  
...  

2010 ◽  
Vol 135 ◽  
pp. S92-S93
Author(s):  
Vincent Dioszeghy ◽  
Lucie Mondoulet ◽  
Veronique Dhelft ◽  
Melanie Ligouis ◽  
Emilie Puteaux ◽  
...  

2021 ◽  
Vol 12 ◽  
Author(s):  
Guirong Liu ◽  
Manman Liu ◽  
Junjuan Wang ◽  
Yao Mou ◽  
Huilian Che

In recent decades, a rapid increase in the prevalence of food allergies has led to extensive research on novel treatment strategies and their mechanisms. Mouse models have provided preliminary insights into the mechanism of epicutaneous immunotherapy (EPIT)-induced immune tolerance. In EPIT, antigen applied on the skin surface can be captured, processed, and presented in the lymph nodes (LNs) by Antigen-presenting cells (APCs). In the LNs, induction of regulatory T cells (Treg cells) requires both direct contact during antigen presentation and indirect mechanisms such as cytokines. Foxp3+CD62L+ Treg cells can exhibit the characteristics of hypomethylation of Foxp3 TSDR and Foxp3-LAP+ Treg cells, which increase the expression of surface tissue-specific homing molecules to exert further sustained systemic immune tolerance. Studies have shown that EPIT is a potential treatment for food allergies and can effectively induce immune tolerance, but its mechanism needs further exploration. Here, we review Treg cells’ role in immune tolerance induced by EPIT and provide a theoretical basis for future research directions, such as the mechanism of EPIT and the development of more effective EPIT treatments.


Autoimmunity ◽  
2009 ◽  
pp. 1-1
Author(s):  
Jose Miguel Sempere-Ortells ◽  
Vicente Perez-Garcia ◽  
Gema Marin-Alberca ◽  
Alejandra Peris-Pertusa ◽  
Jose Miguel Benito ◽  
...  

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