Faculty Opinions recommendation of Five-year oncological outcome after a single fraction of accelerated partial breast irradiation in the elderly.

Author(s):  
Lorenzo Livi ◽  
Isacco Desideri
2018 ◽  
Vol 13 (1) ◽  
Author(s):  
Rémy Kinj ◽  
Marie-Eve Chand ◽  
Jocelyn Gal ◽  
Mathieu Gautier ◽  
Lucile Montagné ◽  
...  

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Rémy Kinj ◽  
Marie-Eve Chand ◽  
Jocelyn Gal ◽  
Mathieu Gautier ◽  
Daniel Lam Cham Kee ◽  
...  

Abstract Background To update the clinical outcome of an elderly women cohort with early breast cancer who underwent accelerated partial breast irradiation (APBI) based on a post-operative single fraction of multicatheter interstitial high dose–rate brachytherapy (MIB). Material and methods A single institution retrospective cohort study was performed focusing on elderly patients (≥ 65 years old) presenting a low-risk breast carcinoma treated by lumpectomy plus axillary evaluation followed by MIB APBI. A single fraction of 16 Gy was prescribed on the 100% isodose. Clinical outcome at 5 years was reported based on local relapse free survival (LRFS), specific survival (SS) and overall survival (OS). Late toxicity was evaluated. Cosmetic results were evaluated clinically by the physician. Results Between January 2012 and August 2015, 48 women (51 lesions) were treated. Median age was 77.7 years (range: 65–92) with a median tumor size of 12 mm (range: 3–32). Five patients (pts) presented an axillary lymph node involvement (4 Nmic, 1 N1). Invasive ductal carcinoma was the most frequent histology type (86.3%). With a median follow–up of 64 months (range: 56–71), no local relapse occurred while 1 pt. developed an axillary relapse (2.1%). No Grade 3 or higher late toxicity was observed while 16 late toxicities occurred (G1: 14 events [87.5%) mainly G1 breast fibrosis). The rate of excellent cosmetic outcome was 76.4%. Conclusion We confirmed the safety of the process and remained encouraging clinical outcome of a post-operative single fraction of MIB ABPI in the elderly. This approach leads to consider a very APBI as an attractive alternative to intra-operative radiation therapy while all the patients will be good candidates for APBI in regards to the post-operative pathological report.


Brachytherapy ◽  
2020 ◽  
Vol 19 (1) ◽  
pp. 90-96 ◽  
Author(s):  
Jean-Michel Hannoun-Lévi ◽  
Daniel Lam Cham Kee ◽  
Jocelyn Gal ◽  
Renaud Schiappa ◽  
Arthur Hannoun ◽  
...  

2014 ◽  
Vol 9 (1) ◽  
pp. 115 ◽  
Author(s):  
Caroline Genebes ◽  
Marie-Eve Chand ◽  
Jocelyn Gal ◽  
Mathieu Gautier ◽  
Ines Raoust ◽  
...  

2020 ◽  
Author(s):  
Shakeel Sumodhee ◽  
Marc PUJALTE-MARTIN ◽  
Jocelyn Gal ◽  
Daniel Lam Cham Kee ◽  
Mathieu Gautier ◽  
...  

Abstract Introduction: To evaluate long term clinical outcome and prognostic factors after accelerated partial breast irradiation (APBI) in the elderly using high-dose-rate interstitial multi-catheter brachytherapy (HIBT).Material and methods: Between 2005 and 2018, 109 patients underwent APBI using HIBT (34 Gy/10f/5d or 32 Gy/8f/4d). Based on a prospective database, outcomes were retrospectively analyzed (local relapse-free survival (LRFS), metastatic-free survival (MFS), specific survival (SS) and overall survival (OS). Prognostic factors were investigated. Late toxicity and cosmetic evaluation were reported.Results: With a median follow-up of 97 months [7–159], median age was 81.7 years [58-89]. According to the GEC-ESTRO APBI classification, 72.5%, 11.9% and 15.6% were classified as low, intermediate and high-risk respectively. The histological type was mainly invasive ductal carcinoma (87.1%). The median tumor size was 10 mm [range 1-35]. Eight-year LRFS, SS and OS were 96.7% [95% CI [0.923; 1]), 96.7% [95% CI [0.924; 1] and 72%[95% CI [0.616; 0.837] respectively. In univariate analysis, APBI classification was not cosidered as prognostic factor, whilemolecular classification was prognostic factor for OS (p<0.0001), SS (p=0.007) and MFS (p=0.009) but not for LR (p=0.586). No Grade ³3 late toxicity was observed while 61 patients (88.4%) and 8 patients (11.6%) presented grade 1 and 2 toxicities respectively. Cosmetic outcome was excellent/good for 96.4%.Conclusion: Long-term follow-up confirms that HIBT is safe and effective for elderly early breast cancer. Our results suggest that selected elderly women presenting with high-risk breast cancer could be also considered for APBI.


2012 ◽  
Vol 03 (05) ◽  
pp. 655-661 ◽  
Author(s):  
Kathleen C. Horst ◽  
Debra M. Ikeda ◽  
Katherine E. Fero ◽  
Jafi A. Lipson ◽  
Sunita Pal ◽  
...  

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