scholarly journals Faculty Opinions recommendation of α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.

2020 ◽  
Author(s):  
Miles Congreve ◽  
Mark Pickworth
Keyword(s):  
Broad Spectrum ◽  
Design Synthesis ◽  
Activity Assessment

scholarly journals α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

2020 ◽  
Vol 63 (9) ◽  
pp. 4562-4578 ◽  
Author(s):  
Linlin Zhang ◽  
Daizong Lin ◽  
Yuri Kusov ◽  
Yong Nian ◽  
Qingjun Ma ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Design Synthesis ◽  
Activity Assessment

scholarly journals Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 2

2020 ◽  
Vol 11 (12) ◽  
pp. 1379-1385
Author(s):  
R. Kirk ◽  
A. Ratcliffe ◽  
G. Noonan ◽  
M. Uosis-Martin ◽  
D. Lyth ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Bacterial Infections ◽  
Rational Design ◽  
Topoisomerase Ii ◽  
Topoisomerase Inhibitors ◽  
Design Synthesis ◽  
Pharmacokinetic Properties ◽  
Spectrum Activity ◽  
Broad Spectrum Activity

We disclose the discovery of REDX07965, a novel tricyclic topoisomerase inhibitor (NTTI) which has broad spectrum activity, favourable in vitro pharmacokinetic properties and selectivity versus human topoisomerase II.

Design, Synthesis, and Biological Evaluation of Hexacyclic Tetracyclines as Potent, Broad Spectrum Antibacterial Agents

2015 ◽  
Vol 58 (11) ◽  
pp. 4703-4712 ◽  
Author(s):  
Cuixiang Sun ◽  
Diana K. Hunt ◽  
Chi-Li Chen ◽  
Yonghong Deng ◽  
Minsheng He ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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