Imidazo[1,2-b]pyridazines, Novel Nucleus with Potent and Broad Spectrum Activity against Human Picornaviruses:  Design, Synthesis, and Biological Evaluation

2003 ◽  
Vol 46 (20) ◽  
pp. 4333-4341 ◽  
Author(s):  
Chafiq Hamdouchi ◽  
Concha Sanchez-Martinez ◽  
Joseph Gruber ◽  
Miriam del Prado ◽  
Javier Lopez ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Spectrum Activity ◽  
Synthesis And Biological Evaluation ◽  
Broad Spectrum Activity

scholarly journals Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 2

2020 ◽  
Vol 11 (12) ◽  
pp. 1379-1385
Author(s):  
R. Kirk ◽  
A. Ratcliffe ◽  
G. Noonan ◽  
M. Uosis-Martin ◽  
D. Lyth ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Bacterial Infections ◽  
Rational Design ◽  
Topoisomerase Ii ◽  
Topoisomerase Inhibitors ◽  
Design Synthesis ◽  
Pharmacokinetic Properties ◽  
Spectrum Activity ◽  
Broad Spectrum Activity

We disclose the discovery of REDX07965, a novel tricyclic topoisomerase inhibitor (NTTI) which has broad spectrum activity, favourable in vitro pharmacokinetic properties and selectivity versus human topoisomerase II.

Design, Synthesis, and Biological Evaluation of Hexacyclic Tetracyclines as Potent, Broad Spectrum Antibacterial Agents

2015 ◽  
Vol 58 (11) ◽  
pp. 4703-4712 ◽  
Author(s):  
Cuixiang Sun ◽  
Diana K. Hunt ◽  
Chi-Li Chen ◽  
Yonghong Deng ◽  
Minsheng He ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of novel 1,2,4-triazolo and 1,2,4-triazino[4,3-a]quinoxalines as potential anticancer and antimicrobial agents

MedChemComm ◽  
2015 ◽  
Vol 6 (1) ◽  
pp. 202-211 ◽  
Author(s):  
Doaa A. E. Issa ◽  
Nargues S. Habib ◽  
Abeer E. Abdel Wahab
Keyword(s):  
Antimicrobial Activity ◽  
Broad Spectrum ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Compound 9a showed dual anticancer and antimicrobial activity and compound 16 showed a broad spectrum antimicrobial activity.

New triarylpyrazoles as broad-spectrum anticancer agents: Design, synthesis, and biological evaluation

2013 ◽  
Vol 65 ◽  
pp. 315-322 ◽  
Author(s):  
Mohammed I. El-Gamal ◽  
Yi Seul Park ◽  
Dae Yoon Chi ◽  
Kyung Ho Yoo ◽  
Chang-Hyun Oh
Keyword(s):  
Broad Spectrum ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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