Faculty Opinions recommendation of Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila.

2020 ◽  
Author(s):  
John R Couchman
Keyword(s):  
Chondroitin Sulfate ◽  
Hedgehog Signaling ◽  
Chondroitin Sulfate Proteoglycan ◽  
Sulfate Proteoglycan

scholarly journals Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila

2018 ◽  
Author(s):  
Masahiko Takemura ◽  
Fredrik Noborn ◽  
Jonas Nilsson ◽  
Eriko Nakato ◽  
Tsu-Yi Su ◽  
...  
Keyword(s):  
Cell Surface ◽  
Chondroitin Sulfate ◽  
Hedgehog Signaling ◽  
Transmembrane Protein ◽  
Wing Disc ◽  
Chondroitin Sulfate Proteoglycan ◽  
Growth Factor Signaling ◽  
Sulfate Proteoglycan ◽  
Sugar Chain ◽  
Hh Signaling

AbstractProteoglycans, a class of carbohydrate-modified proteins, often modulate growth factor signaling on the cell surface. However, the molecular mechanism by which proteoglycans regulate signal transduction is largely unknown. In this study, using a recently-developed glycoproteomic method, we found that Windpipe (Wdp) is a novel chondroitin sulfate proteoglycan (CSPG) in Drosophila. Wdp is a single-pass transmembrane protein with leucin-rich repeat (LRR) motifs and bears three CS sugar chain attachment sites in the extracellular domain. Here we show that Wdp modulates the Hedgehog (Hh) pathway. Overexpression of wdp inhibits Hh signaling in the wing disc, which is dependent on its CS chains and the LRR motifs. Conversely, loss of wdp leads to the upregulation of Hh signaling. Furthermore, knockdown of wdp increase the cell surface accumulation of Smoothened (Smo), suggesting that Wdp inhibits Hh signaling by regulating Smo stability. Our study demonstrates a novel role of CSPG in regulating Hh signaling.

scholarly journals Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila

2020 ◽  
Vol 31 (8) ◽  
pp. 813-824
Author(s):  
Masahiko Takemura ◽  
Fredrik Noborn ◽  
Jonas Nilsson ◽  
Nanako Bowden ◽  
Eriko Nakato ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Hedgehog Signaling ◽  
Extracellular Domain ◽  
Chondroitin Sulfate Proteoglycan ◽  
Sulfate Proteoglycan ◽  
Sugar Chains

Using a recently developed glycoproteomic method, we identified a novel chondroitin sulfate proteoglycan, Windpipe (Wdp), in Drosophila. Wdp has three chondroitin sulfate sugar chains on the extracellular domain. We show that Wdp negatively regulates Hedgehog signaling via the chondroitin sulfate sugar chains.

scholarly journals Biosynthesis of Chondroitin Sulfate Proteoglycan

1972 ◽  
Vol 247 (12) ◽  
pp. 3838-3847
Author(s):  
John R. Baker ◽  
Lennart Rodén ◽  
Allen C. Stoolmiller
Keyword(s):  
Chondroitin Sulfate ◽  
Chondroitin Sulfate Proteoglycan ◽  
Sulfate Proteoglycan

scholarly journals Brevican, a Chondroitin Sulfate Proteoglycan of Rat Brain, Occurs as Secreted and Cell Surface Glycosylphosphatidylinositol-anchored Isoforms

1995 ◽  
Vol 270 (45) ◽  
pp. 27206-27212 ◽  
Author(s):  
Constanze I. Seidenbecher ◽  
Karin Richter ◽  
Uwe Rauch ◽  
Reinhard Fässler ◽  
Craig C. Garner ◽  
...  
Keyword(s):  
Cell Surface ◽  
Chondroitin Sulfate ◽  
Rat Brain ◽  
Chondroitin Sulfate Proteoglycan ◽  
Sulfate Proteoglycan
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