Faculty Opinions recommendation of 3D genomics across the tree of life reveals condensin II as a determinant of architecture type.

Author(s):  
Masaki Sasai
Keyword(s):  
Science ◽  
2021 ◽  
Vol 372 (6545) ◽  
pp. 984-989
Author(s):  
Claire Hoencamp ◽  
Olga Dudchenko ◽  
Ahmed M. O. Elbatsh ◽  
Sumitabha Brahmachari ◽  
Jonne A. Raaijmakers ◽  
...  

We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state, centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physical model in which lengthwise compaction of chromosomes by condensin II during mitosis determines chromosome-scale genome architecture, with effects that are retained during the subsequent interphase. This mechanism likely has been conserved since the last common ancestor of all eukaryotes.


2012 ◽  
Vol 3 (3) ◽  
pp. 267-301
Author(s):  
Michaela Bauks

Interpretations of the trees in the Garden of Eden misunderstand their significance by focusing on sin or a theological “fall.” A tradition-historical approach to the motif of trees in ancient Near Eastern literature and imagery reveals their multivalent quality. Trees are connected with fertility and goddess devotion but also with the power and divine sanction given to kings and dynasties, and with the potency of sacred space, on which humans and the divine come together and meet. As cross-temporal motifs, trees are regularly associated with life-giving and blessing (a plant of rejuvenation; a tree of life); a connection of trees to knowledge and meaning appears as well, in wisdom literature, and in the book of 1 Enoch. Language of a world tree or cosmic tree, though useful conceptually, is a modern imposition on the ancient evidence. More evident from the ancient setting is the image of felling trees, which indicates the downfall of human leaders, especially kings, because of their hubris. Ultimately, sacred trees have an ambivalent value, as a source of both contestation and progress.


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