Faculty Opinions recommendation of The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses.

2011 ◽  
Author(s):  
Bruce Zuraw ◽  
Taylor Doherty
Keyword(s):  
Extracellular Atp ◽  
Danger Signal ◽  
Airborne Allergen

scholarly journals The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses

2011 ◽  
Vol 186 (7) ◽  
pp. 4375-4387 ◽  
Author(s):  
Hideaki Kouzaki ◽  
Koji Iijima ◽  
Takao Kobayashi ◽  
Scott M. O’Grady ◽  
Hirohito Kita
Keyword(s):  
Extracellular Atp ◽  
Danger Signal ◽  
Airborne Allergen

Inflammasome activation by danger signals: extracellular ATP and pH

Inflammasome ◽  
2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Takato Takenouchi ◽  
Mitsutoshi Tsukimoto ◽  
Makoto Hashimoto ◽  
Hiroshi Kitani
Keyword(s):  
P2x7 Receptor ◽  
Extracellular Atp ◽  
Innate Immune ◽  
Inflammasome Activation ◽  
Danger Signal ◽  
Interleukin 18 ◽  
Extracellular Acidification ◽  
Danger Signals ◽  
Acidic Extracellular Ph ◽  
Pro Inflammatory Cytokines

AbstractExtracellular ATP has been recognized as a danger signal that alerts the innate immune system. High extracellular concentrations of ATP can trigger the maturation and secretion of pro-inflammatory cytokines (e.g., interleukin-1β and interleukin-18) through the inflammasome-dependent activation of caspase-1. The P2X7 receptor, an ATP-gated cation channel, plays a pivotal role in ATP-induced NLRP3 inflammasome assembly. Recently, intriguing evidence has emerged that acidic extracellular pH acts as a danger signal that activates inflammasomes. Extracellular acidification frequently occurs at sites of inflammation, infection, or injury. In addition, large amounts of ATP are readily released into the extracellular space from damaged cells at such sites. Thus, it is assumed that the ATP/P2X7 receptor pathway regulates the inflammatory response under acidic extracellular conditions. Here, we briefly discuss the mutual effects of extracellular ATP and pH on inflammasome activation and consider their roles in the regulation of inflammation.

Extracellular ATP Is a Danger Signal Activating P2X7Receptor in Lung Inflammation and Fibrosis

2010 ◽  
Vol 182 (6) ◽  
pp. 774-783 ◽  
Author(s):  
Nicolas Riteau ◽  
Pamela Gasse ◽  
Louis Fauconnier ◽  
Aurélie Gombault ◽  
Marion Couegnat ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Extracellular Atp ◽  
Danger Signal

scholarly journals Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection

Cell Reports ◽  
2017 ◽  
Vol 21 (12) ◽  
pp. 3414-3426 ◽  
Author(s):  
Joaquín Amores-Iniesta ◽  
Maria Barberà-Cremades ◽  
Carlos M. Martínez ◽  
José A. Pons ◽  
Beatriz Revilla-Nuin ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Allograft Rejection ◽  
Extracellular Atp ◽  
Danger Signal ◽  
Skin Allograft

Assessing Extracellular ATP as Danger Signal In Vivo: The pmeLuc System

2016 ◽  
pp. 115-129 ◽  
Author(s):  
Francesco Di Virgilio ◽  
Paolo Pinton ◽  
Simonetta Falzoni
Keyword(s):  
Extracellular Atp ◽  
Danger Signal

scholarly journals The Danger Signal Extracellular ATP Is Involved in the Immunomediated Damage of α-Sarcoglycan–Deficient Muscular Dystrophy

2019 ◽  
Vol 189 (2) ◽  
pp. 354-369 ◽  
Author(s):  
Elisabetta Gazzerro ◽  
Serena Baratto ◽  
Stefania Assereto ◽  
Simona Baldassari ◽  
Chiara Panicucci ◽  
...  
Keyword(s):  
Muscular Dystrophy ◽  
Extracellular Atp ◽  
Danger Signal

Extracellular ATP is a danger signal activating P2X7 Receptor in a LPS mediated inflammation (ARDS)

2015 ◽  
Author(s):  
Sanja Cicko ◽  
Anja Meyer ◽  
Nicolas Ehrat ◽  
Cemil Korcan Ayata ◽  
Andreas Zech ◽  
...  
Keyword(s):  
P2x7 Receptor ◽  
Extracellular Atp ◽  
Danger Signal

Extracellular ATP, a danger signal, is recognized by DORN1 in Arabidopsis

2014 ◽  
Vol 463 (3) ◽  
pp. 429-437 ◽  
Author(s):  
Jeongmin Choi ◽  
Kiwamu Tanaka ◽  
Yan Liang ◽  
Yangrong Cao ◽  
Sang Yeol Lee ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Stress Responses ◽  
Early Stage ◽  
Plant Stress ◽  
Extracellular Atp ◽  
Receptor Kinase ◽  
Danger Signal ◽  
Lectin Receptor ◽  
Plant Stress Responses

ATP, the universal energy currency of all organisms, is released into the extracellular matrix and serves as a signal among cells, where it is referred to as an extracellular ATP. Although a signalling role for extracellular ATP has been well studied in mammals over the last 40 years, investigations of such a role in plants are at an early stage. Recently, the first plant receptor for extracellular ATP, DOes not Respond to Nucleotides (DORN1), was identified in Arabidopsis thaliana by mutant screening. DORN1 encodes a legume-type lectin receptor kinase that is structurally distinct from the mammalian extracellular ATP receptors. In the present review, we highlight the genetic and biochemical evidence for the role of DORN1 in extracellular ATP signalling, placing this within the wider context of extracellular ATP signalling during plant stress responses.

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