Rapid tablet swelling and disintegration during exposure to brightness-mode ultrasound
Keyword(s):
Abstract Controlled tablet disintegration is useful for chemical consistency checks. This study monitored the swelling of 54 analgesia tablets from two different batches, during 13–6-MHz brightness-mode sonication and simultaneous video recording. The tablets were placed on an acoustic reflector inside a container and sonicated from the top. Sonication shortened the displacement half-life by 17%–27%. During tablet swelling, their speed of sound increased linearly, confirming the linearity of the this process. Diagnostic ultrasound significantly decreased tablet disintegration times, supporting the ultrasound–microbubble interaction hypothesis.
2019 ◽
Vol 4
(2)
◽
pp. 356-362
2020 ◽
Vol 46
(11)
◽
pp. 3172
Keyword(s):
Keyword(s):
Keyword(s):
1996 ◽
Vol 36
(1-2)
◽
pp. 87-91
Keyword(s):