scholarly journals Molecular Pathogenicity of Wild-Endotoxin Derived from Burned Patient’s Skin and Proposed Effectiveness of Calcium Channel Inhibitors

2021 ◽  
Vol 34 (3) ◽  
pp. 203-210
Author(s):  
Mojtaba Hedayati Ch ◽  
Mahla Shahriari ◽  
Mohammadreza Mobayen ◽  
Mahmood Abedinzade ◽  
Atabak Nagheli ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Inhibitors

scholarly journals Neuronal calcium channel inhibitors. Synthesis of omega-conotoxin GVIA and effects on 45Ca uptake by synaptosomes.

1987 ◽  
Vol 262 (3) ◽  
pp. 1194-1198
Author(s):  
J Rivier ◽  
R Galyean ◽  
W R Gray ◽  
A Azimi-Zonooz ◽  
J M McIntosh ◽  
...  
Keyword(s):  
Calcium Channel ◽  
45Ca Uptake ◽  
Calcium Channel Inhibitors ◽  
Neuronal Calcium Channel

Effects of calcium channel inhibitors on the hypothermic response to oxotremorine in normo and hypercholinergic rats

1991 ◽  
Vol 43 (6) ◽  
pp. 436-439 ◽  
Author(s):  
OLGIERD PUCILOWSKI ◽  
DAVID H. OVERSTREET ◽  
AMIR H. REZVANI ◽  
DAVID S. JANOWSKY
Keyword(s):  
Calcium Channel ◽  
Hypothermic Response ◽  
Calcium Channel Inhibitors

Two New Classes of T-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear

2015 ◽  
Vol 17 (12) ◽  
pp. 3082-3085 ◽  
Author(s):  
Feng-Jiao Zhou ◽  
Yin Nian ◽  
Yongming Yan ◽  
Ye Gong ◽  
Qi Luo ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Inhibitors

scholarly journals Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Limei Wan ◽  
Weibin Wu ◽  
Shunjun Jiang ◽  
Shanhe Wan ◽  
Dongmei Meng ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Calcium Channel ◽  
Lavage Fluid ◽  
Cell Number ◽  
Effector Cells ◽  
Potent Inhibition ◽  
Tnf Α ◽  
Calcium Channel Inhibitors

Recent studies have illuminated that blocking Ca2+ influx into effector cells is an attractive therapeutic strategy for lung injury. We hypothesize that T-type calcium channel may be a potential therapeutic target for acute lung injury (ALI). In this study, the pharmacological activity of mibefradil (a classical T-type calcium channel inhibitor) was assessed in a mouse model of lipopolysaccharide- (LPS-) induced ALI. In LPS challenged mice, mibefradil (20 and 40 mg/kg) dramatically decreased the total cell number, as well as the productions of TNF-α and IL-6 in bronchoalveolar lavage fluid (BALF). Mibefradil also suppressed total protein concentration in BALF, attenuated Evans blue extravasation, MPO activity, and NF-κB activation in lung tissue. Furthermore, flunarizine, a widely prescripted antimigraine agent with potent inhibition on T-type channel, was also found to protect mice against lung injury. These data demonstrated that T-type calcium channel inhibitors may be beneficial for treating acute lung injury. The important role of T-type calcium channel in the acute lung injury is encouraged to be further investigated.

Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain

2013 ◽  
Vol 23 (17) ◽  
pp. 4857-4861 ◽  
Author(s):  
Xenia Beebe ◽  
Clinton M. Yeung ◽  
Daria Darczak ◽  
Shashank Shekhar ◽  
Timothy A. Vortherms ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Calcium Channel ◽  
Calcium Channel Inhibitors ◽  
Orally Active

scholarly journals Calcium channel inhibitors suppress the morphine-withdrawal syndrome in rats

1986 ◽  
Vol 88 (3) ◽  
pp. 561-567 ◽  
Author(s):  
F. Bongianni ◽  
V. Carla' ◽  
F. Moroni ◽  
D.E. Pellegrini-Giampietro
Keyword(s):  
Calcium Channel ◽  
Withdrawal Syndrome ◽  
Morphine Withdrawal ◽  
Calcium Channel Inhibitors

Calcium channel inhibitors prevent apomorphine- and oxytocin-induced penile erection and yawning in male rats

1989 ◽  
Vol 166 (3) ◽  
pp. 515-518 ◽  
Author(s):  
Antonio Argiolas ◽  
Maria Rosaria Melis ◽  
Gian Luigi Gessa
Keyword(s):  
Calcium Channel ◽  
Penile Erection ◽  
Male Rats ◽  
Calcium Channel Inhibitors

Calcium Channel Inhibitors for Identification of Mechanisms and Treatment of Hypertension

1982 ◽  
Vol 4 (Supplement 3) ◽  
pp. S269
Author(s):  
Fritz R. B??hler ◽  
U. Lennart Hulth??n ◽  
Peter Bolli
Keyword(s):  
Calcium Channel ◽  
Treatment Of Hypertension ◽  
Calcium Channel Inhibitors

Adamantane amine derivatives as dual acting NMDA receptor and voltage-gated calcium channel inhibitors for neuroprotection

MedChemComm ◽  
2014 ◽  
Vol 5 (11) ◽  
pp. 1678-1684 ◽  
Author(s):  
Yakub E. Kadernani ◽  
Frank T. Zindo ◽  
Erika Kapp ◽  
Sarel F. Malan ◽  
Jacques Joubert
Keyword(s):  
Nmda Receptor ◽  
Calcium Channel ◽  
Voltage Gated ◽  
Inhibitory Activities ◽  
Calcium Channel Inhibitors ◽  
Voltage Gated Calcium Channel

A series of adamantane-derived compounds, structurally similar to NGP1-01, were synthesised and showed significant dual NMDA receptor and VGCC inhibitory activities.

scholarly journals Structure–activity relationships of diphenylpiperazine N-type calcium channel inhibitors

2010 ◽  
Vol 20 (4) ◽  
pp. 1378-1383 ◽  
Author(s):  
Hassan Pajouhesh ◽  
Zhong-Ping Feng ◽  
Yanbing Ding ◽  
Lingyun Zhang ◽  
Hossein Pajouhesh ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Calcium Channel Inhibitors
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