scholarly journals Non-steroidal anti-inflammatory drug-induced small bowel injuries identified by double-balloon endoscopy

2005 ◽  
Vol 11 (31) ◽  
pp. 4861 ◽  
Author(s):  
Yoshikazu Hayashi
Keyword(s):  
Small Bowel ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Double Balloon Endoscopy ◽  
Double Balloon ◽  
Anti Inflammatory

scholarly journals Non-steroidal Anti-inflammatory Drug Induced Injury to the Small Intestine

2010 ◽  
Vol 53 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Ilja Tachecí ◽  
Marcela Kopáčová ◽  
Stanislav Rejchrt ◽  
Jan Bureš
Keyword(s):  
Small Bowel ◽  
Drug Induced ◽  
Double Balloon Enteroscopy ◽  
Faecal Calprotectin ◽  
Faecal Excretion ◽  
Inflammatory Drug ◽  
Balloon Enteroscopy ◽  
Double Balloon ◽  
Nsaid Enteropathy ◽  
Anti Inflammatory

Non-steroidal anti-inflammatory drug (NSAIDs) induced enteropathy represents an important complication of one of the most commonly used drugs worldwide. Due to previous diagnostics difficulties the real prevalence of this disease was underestimated for a long time. The pathogenesis of NSAID-enteropathy is more multifactorial and complex than formerly assumed but has still not been fully uncovered. A combination of the local and systemic effect plays an important role in pathogenesis. Thanks to novel enteroscopy methods (wireless capsule endoscopy, double balloon enteroscopy), small bowel lesions are described in a substantial section of NSAID users although most are clinically asymptomatic. The other non-invasive tests (small bowel permeability, faecal calprotectin, scintigraphy using faecal excretion of 111-indium-labelled leukocytes etc.) proposed for diagnostics are not generally used in clinical practice, mainly because of their non-specificity. Despite intensive research into possible treatment, the main measure for patients with NSAID-enteropathy is still withdrawal of NSAIDs. Double balloon enteroscopy plays an important role in the treatment of complications (bleeding, strictures).

Prevalence of non-steroidal anti-inflammatory drug-induced enteropathy determined by double-balloon endoscopy: A Japanese multicenter study

2008 ◽  
Vol 43 (4) ◽  
pp. 490-496 ◽  
Author(s):  
Takayuki Matsumoto ◽  
Tetsuji Kudo ◽  
Motohiro Esaki ◽  
Tomonori Yano ◽  
Hironori Yamamoto ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Double Balloon Endoscopy ◽  
Double Balloon ◽  
Anti Inflammatory

scholarly journals Non-steroidal anti-inflammatory drug-induced diaphragm disease: an uncommon cause of small bowel obstruction

2016 ◽  
Vol 98 (8) ◽  
pp. e189-e191 ◽  
Author(s):  
MME Coolsen ◽  
SJ Leedham ◽  
RJ Guy
Keyword(s):  
Small Bowel ◽  
Small Bowel Obstruction ◽  
Bowel Obstruction ◽  
Small Bowel Resection ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Diaphragm Disease ◽  
Anti Inflammatory ◽  
Diagnostic Work ◽  
Work Up

Surgeons frequently deal with small bowel obstruction. However, small bowel obstruction caused by non-steroidal anti-inflammatory drug (NSAID)-induced diaphragm disease is very rare. The diagnosis is challenging, as symptoms are often non-specific and radiological studies remain inconclusive. We present a case of a 63-year-old man who, after an extensive diagnostic work-up and small bowel resection for obstructive symptoms, was finally diagnosed with NSAID-induced diaphragm disease as confirmed by histology. An unusual aspect of this case is that the patient stopped using NSAIDs after he was diagnosed with a gastric ulcer 2–years previously. This suggests that NSAID-induced diaphragms of the small bowel take some time to develop and underlines the importance of careful history taking.

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