Cascade radical reaction of substrates with a carbon–carbon triple bond as a radical acceptor
2013 ◽
Vol 9
◽
pp. 1148-1155
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Keyword(s):
The limitation of hydroxamate ester as a chiral Lewis acid coordination moiety was first shown in an intermolecular reaction involving a radical addition and sequential allylation processes. Next, the effect of hydroxamate ester was studied in the cascade addition–cyclization–trapping reaction of substrates with a carbon–carbon triple bond as a radical acceptor. When substrates with a methacryloyl moiety and a carbon–carbon triple bond as two polarity-different radical acceptors were employed, the cascade reaction proceeded effectively. A high level of enantioselectivity was also obtained by a proper combination of chiral Lewis acid and these substrates.
1999 ◽
Vol 10
(12)
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pp. 2417-2428
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Keyword(s):
2004 ◽
Vol 126
(17)
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pp. 5366-5367
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1997 ◽
Vol 3
(9)
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pp. 1472-1481
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Keyword(s):