PRECLINICAL STUDIES TO ASSESS ACUTE AND CHRONIC TOXICITIES OF A CANDIDATE DRUG BASED ON COMPLEMENT C3 NEODETERMINANT RECOMBINANT HUMANIZED ANTIBODY FOR TREATMENT OF TRAUMATIC BRAIN INJURIES

2021 ◽  
Vol 1 (19) ◽  
pp. 48-49
Author(s):  
A.V. Trofimov ◽  
A.V. Zhakhov ◽  
S.V. Rodin ◽  
N.P. Gorbunov ◽  
A.V. Petrov ◽  
...  
Keyword(s):  
Brain Injuries ◽  
Traumatic Brain Injuries ◽  
Low Risk ◽  
Complement C3 ◽  
Preclinical Studies ◽  
Class Iii ◽  
Humanized Antibody ◽  
Candidate Drug

A drug based on complement C3 neodeterminant recombinant humanized antibody for the treatment of traumatic brain injuries belongs to the class III of low-risk drugs.

scholarly journals Preclinical Studies into Specific Toxicity of a Candidate Drug Based on Complement C3 neodeterminant Recombinant Humanized Antibody for Treating Traumatic Brain Injuries

Biomeditsina ◽  
2021 ◽  
Vol 17 (4) ◽  
pp. 68-80
Author(s):  
K. A. Nekrasova ◽  
A. V. Trofimov ◽  
A. V. Zhahov ◽  
S. V. Rodin ◽  
N. P. Gorbunov ◽  
...  
Keyword(s):  
Immune Responses ◽  
Dosage Form ◽  
Brain Injuries ◽  
Cell Activity ◽  
Complement C3 ◽  
Preclinical Studies ◽  
Female Reproduction ◽  
Humanized Antibody ◽  
Candidate Drug ◽  
Reproduction Toxicity

This study aims to assess the specific toxicity (allergenicity, immunotoxicity and reproduction toxicity) of a dosage form of complement C3 neodeterminant recombinant humanized antibody. The reactions of general anaphylaxis, active cutaneous anaphylaxis and delayed-type reaction demonstrated no drug-related signs of experimental animal sensitization and immediate or delayed hypersensitivity in the treated animals. It was found that, in doses exceeding significantly the expected human therapeutic dose, the drug has no effect on humoral and cell-mediated immune responses. In addition, the drug does not suppress the phagocytic cell activity thereby indicating the absence of immunotoxic effect. Moreover, the drug has no adverse effects on male and female reproduction, progeny embryonal development, as well as prenatal and postnatal progeny development. The obtained data can be used in future clinical studies of the drug safety.

Mild Traumatic Brain Injuries in Low-Risk Trauma Patients

1996 ◽  
Vol 41 (6) ◽  
pp. 976-980 ◽  
Author(s):  
Jodi Chambers ◽  
Sharon S. Cohen ◽  
Lee Hemminger ◽  
J. Adair Prall ◽  
John S. Nichols
Keyword(s):  
Brain Injuries ◽  
Traumatic Brain Injuries ◽  
Low Risk ◽  
Trauma Patients ◽  
Mild Traumatic Brain Injuries

Going Beyond Admiring Traumatic Brain Injuries

PsycCRITIQUES ◽  
2006 ◽  
Vol 51 (11) ◽  
Author(s):  
Walter Erich Penk
Keyword(s):  
Brain Injuries ◽  
Traumatic Brain Injuries

Severe traumatic brain injuries in the elderly

2009 ◽  
Author(s):  
N. Syrmos ◽  
Ch. Iliadis ◽  
V. Valadakis ◽  
K. Grigoriou ◽  
K. Paltatzidou ◽  
...  
Keyword(s):  
Brain Injuries ◽  
The Elderly ◽  
Traumatic Brain Injuries
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