Choroidal Neovascularization Secondary to Angioid Streaks

Angioid streaks (AS) are characterized by pathological changes at the level of the Bruch membrane. The manifestations are usually bilateral. Patients may be asymptomatic unless the macula is involved. The main vision-threatening complication of AS is choroidal neovascularization (CNV) which develops in more than 2/3 of cases. The natural course of CNV associated with AS has a poor prognosis if left untreated. Several treatment methods have been proposed up to date. Laser photocoagulation, photodynamic therapy (PDT), transpupillary thermotherapy, photothrombosis with indocyanine green, and surgical therapy have been done in these cases. Nowadays, intravitreal anti-VEGF injections are widely used in the treatments of CNV secondary to AS.