scholarly journals Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms and susceptibility to recurrent pregnancy loss

2018 ◽  
Author(s):  
Domenico Dell'Edera ◽  
Antonella L'Episcopia ◽  
Francesca Simone ◽  
Maria Lupo ◽  
Annunziata Epifania ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Methylenetetrahydrofolate Reductase ◽  
Reductase Gene ◽  
Methylenetetrahydrofolate Reductase Gene

scholarly journals The importance of MTHFR gene mutation detection in patient with recurrent miscarriages

Genetika ◽  
2015 ◽  
Vol 47 (2) ◽  
pp. 609-616
Author(s):  
Klaudija Daugėlaitė ◽  
Danielius Serapinas
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Methylenetetrahydrofolate Reductase ◽  
Molecular Genetic ◽  
Mthfr Gene ◽  
Chromosome 1 ◽  
Recurrent Miscarriages ◽  
Reductase Gene ◽  
Methylenetetrahydrofolate Reductase Gene

Homocysteine is an enzyme encoded by MTHFR (methylenetetrahydrofolate reductase) gene located on chromosome 1. Mutations in MTHFR gene may result in the afflicted metabolism of homocysteine and thus might increase the risk of recurrent miscarriages. In some cases, recurrent pregnancy loss could be prevented by prescribing folic acid and B group vitamin supplements. The demand of MTHFR gene sequencing for variations is commonly overlooked by doctors or genetic counsellors. To highlight this problem we present a case study of recurrent miscarriages in a patient with a homozygous c. 655C>T variation in MTHFR gene. Moreover, we discuss the need of molecular genetic testing for MTHFR gene variations in patients with recurrent miscarriages and the treatment of hyperhomocysteinemia.

Methylenetetrahydrofolate reductase gene C677T, A1298C polymorphisms and pre-eclampsia risk: a meta-analysis

2014 ◽  
Vol 41 (8) ◽  
pp. 5435-5448 ◽  
Author(s):  
Xing Li ◽  
Ya L. Luo ◽  
Qiong H. Zhang ◽  
Chen Mao ◽  
Xi W. Wang ◽  
...  
Keyword(s):  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Reductase Gene ◽  
Methylenetetrahydrofolate Reductase Gene
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