Unpredicted Severe Toxicity after 5-Fluorouracil Treatment due to Dihydropyrimidine Dehydrogenase Deficiency

Severe Toxicity ◽

5-Fluorouracil-related severe toxicity: A comparison of different methods for the pretherapeutic detection of dihydropyrimidine dehydrogenase deficiency

Cancer Letters ◽

10.1016/j.canlet.2006.09.006 ◽

2007 ◽

Vol 249 (2) ◽

pp. 271-282 ◽

Cited By ~ 137

Author(s):

M. Boisdron-Celle ◽

G. Remaud ◽

S. Traore ◽

A.L. Poirier ◽

L. Gamelin ◽

...

Keyword(s):

Severe Toxicity ◽

Dihydropyrimidine dehydrogenase deficiency in patients with severe toxicity after 5-fluorouracil: a retrospective single-center study

Annals of Gastroenterology ◽

10.20524/aog.2020.0551 ◽

2020 ◽

Author(s):

Stephanie Detailleur

Keyword(s):

Severe Toxicity ◽

Single Center ◽

Single Center Study ◽

Dihydropyrimidine Dehydrogenase Deficiency ◽

Center Study

Prevention of 5-fluorouracil–induced early severe toxicity by pre-therapeutic dihydropyrimidine dehydrogenase deficiency screening: The multiparametric approach is not convincing

Seminars in Oncology ◽

10.1053/j.seminoncol.2017.06.001 ◽

2017 ◽

Vol 44 (2) ◽

pp. 159-160 ◽

Cited By ~ 2

Author(s):

Marie-Christine Etienne-Grimaldi ◽

Chantal Barin Le Guellec ◽

Jean-Christophe Boyer ◽

Etienne Chatelut ◽

Alexandre Evrard ◽

...

Keyword(s):

Severe Toxicity ◽

Deficiency Screening ◽

Prevention of 5-fluorouracil-induced early severe toxicity by pre-therapeutic dihydropyrimidine dehydrogenase deficiency screening: Assessment of a multiparametric approach

Seminars in Oncology ◽

10.1053/j.seminoncol.2017.02.008 ◽

2017 ◽

Vol 44 (1) ◽

pp. 13-23 ◽

Cited By ~ 20

Author(s):

Michele Boisdron-Celle ◽

Olivier Capitain ◽

Roger Faroux ◽

Christophe Borg ◽

Jean Philippe Metges ◽

...

Keyword(s):

Severe Toxicity ◽

Screening Assessment ◽

Deficiency Screening ◽

P-297 Upfront dihydropyrimidine dehydrogenase deficiency detection to secure 5-FU or capecitabine administration: Application to colorectal cancer patients

Annals of Oncology ◽

10.1016/j.annonc.2021.05.351 ◽

2021 ◽

Vol 32 ◽

pp. S198

Author(s):

N. Mkedder ◽

S. Ghomari-Bezzar

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Colorectal Cancer Patients ◽

Reversible Leukoencephalopathy With Stroke-Like Presentation in a Patient With 5-Dihydropyrimidine Dehydrogenase Deficiency Treated With Continuous 5-Fluorouracil Infusion

Clinical Colorectal Cancer ◽

10.1016/j.clcc.2012.01.004 ◽

2012 ◽

Vol 11 (3) ◽

pp. 215-217 ◽

Cited By ~ 5

Author(s):

Jia Li ◽

James J. Lee ◽

Edward Chu ◽

Joachim M. Baehring

Keyword(s):

Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome

Cancer ◽

10.1002/1097-0142(19910801)68:3<499::aid-cncr2820680309>3.0.co;2-f ◽

1991 ◽

Vol 68 (3) ◽

pp. 499-501 ◽

Cited By ~ 125

Author(s):

Barry E. Harris ◽

John T. Carpenter ◽

Robert B. Diasio

Keyword(s):

Fluorouracil Toxicity ◽

Dihydropyrimidine Dehydrogenase Deficiency Caused by a Novel Genomic Deletion c.505_513del ofDPYD

Nucleosides Nucleotides & Nucleic Acids ◽

10.1080/15257771003730227 ◽

2010 ◽

Vol 29 (4-6) ◽

pp. 509-514 ◽

Cited By ~ 3

Author(s):

A. B. P. van Kuilenburg ◽

J. Meijer ◽

G. Gökcay ◽

T. Baykal ◽

M. E. Rubio-Gozalbo ◽

...

Keyword(s):

Genomic Deletion ◽

Dihydropyrimidine Dehydrogenase Deficiency

Encyclopedia of Molecular Mechanisms of Disease ◽

10.1007/978-3-540-29676-8_491 ◽

2009 ◽

pp. 534-535

Author(s):

Dieter Metze ◽

Tam Nguyen ◽

Birgit Haack ◽

Alexander K. C. Leung ◽

Noriko Miyake ◽

...

Keyword(s):

Molecular Genetics, Biochemistry and Clinical Aspects of Inherited Disorders of Purine and Pyrimidine Metabolism ◽

Dihydropyrimidine Dehydrogenase Deficiency: Biochemical and Genetic Basis

10.1007/978-3-642-84962-6_24 ◽

1993 ◽

pp. 176-182

Author(s):

R. A. De Abreu

Keyword(s):

Genetic Basis ◽