scholarly journals Screening of cytotoxicity and DNA topoisomerase IIa inhibitory activity of Turkish Onosma species

2021 ◽  
Vol 45 (SI-2) ◽  
pp. 776-788
Author(s):  
Özge GÜZEL ◽  
Seda DUMAN ◽  
Sinem YILMAZ ◽  
Çiğdem KARAKOYUN ◽  
Demet KUL ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Dna Topoisomerase ◽  
Topoisomerase Iia

ChemInform Abstract: Syntheses of Novel Antitumor Dihydroxanthone Derivatives with Inhibitory Activity Against DNA Topoisomerase II.

ChemInform ◽  
2010 ◽  
Vol 30 (52) ◽  
pp. no-no
Author(s):  
Seiichi Sato ◽  
Yasuyo Suga ◽  
Toshihiko Yoshimura ◽  
Ryusuke Nakagawa ◽  
Takashi Tsuji ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase

scholarly journals Phaeophytins from Thyrsacanthus ramosissimus Moric. with inhibitory activity on human dna topoisomerase II-α

Química Nova ◽  
2012 ◽  
Vol 35 (11) ◽  
pp. 2222-2225 ◽  
Author(s):  
Analúcia Guedes Silveira Cabral ◽  
Fábio Henrique Tenório-Souza ◽  
Marcelo Dantas Moura ◽  
Sabrina Gondim Ribeiro Mota ◽  
Antônio Cláudio da Silva Lins ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Human Dna

scholarly journals TAN-1496 A, C and E, diketopiperazine antibiotics with inhibitory activity against mammalian DNA topoisomerase I.

1994 ◽  
Vol 47 (11) ◽  
pp. 1202-1218 ◽  
Author(s):  
YASUNORI FUNABASHI ◽  
TAKASHI HORIGUCHI ◽  
SHIGEMI IINUMA ◽  
SEIICHI TANIDA ◽  
SETSUO HARADA
Keyword(s):  
Inhibitory Activity ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase

scholarly journals DNA Topoisomerase I Inhibitory Activity of Quinochalcone C-glycosides from the Florets of Carthamus tinctorius

2017 ◽  
Vol 12 (11) ◽  
pp. 1934578X1701201
Author(s):  
Shi-Jun Yue ◽  
Wen-Xiao Wang ◽  
Cheng Qu ◽  
Lan-Ting Xin ◽  
Yu-Ping Tang ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Dna Cleavage ◽  
Topoisomerase I ◽  
Docking Study ◽  
Carthamus Tinctorius ◽  
In Vitro Cytotoxicity ◽  
Molecular Docking Study ◽  
Dna Topoisomerase ◽  
Cleavage Complex

The DNA topoisomerase (Topo) I inhibitory activity of six quinochalcone C-glycosides (QCGs) isolated from the florets of Carthamus tinctorius were evaluated in vitro. Among them, anhydrosafflor yellow B (AHSYB, 4) and carthorquinoside B (6) could inhibit DNA Topo I at concentrations as low as 100 μM. Molecular docking study revealed that both of them have the capacity to stabilize Topo I-DNA cleavage complex in silico interacting with the essential binding sites, such as Arg364, Thr718 and TGP11. Besides, both compounds 4 and 6 exhibited no antitumor activity by in vitro cytotoxicity assays.

Syntheses of novel antitumor dihydroxanthone derivatives with inhibitory activity against DNA topoisomerase II

1999 ◽  
Vol 9 (18) ◽  
pp. 2653-2656 ◽  
Author(s):  
Seiichi Sato ◽  
Yasuyo Suga ◽  
Toshihiko Yoshimura ◽  
Ryusuke Nakagawa ◽  
Takashi Tsuji ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase

ChemInform Abstract: New Naphthacenecarboxamide Antibiotics, TAN-1518 A and B, have Inhibitory Activity Against Mammalian DNA Topoisomerase I.

ChemInform ◽  
2010 ◽  
Vol 25 (45) ◽  
pp. no-no
Author(s):  
T. HORIGUCHI ◽  
K. HAYASHI ◽  
S. TSUBOTANI ◽  
S. IINUMA ◽  
S. HARADA ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase

Cytotoxicity and DNA topoisomerase inhibitory activity of constituents isolated from the fruits ofEvodia officinalis

2006 ◽  
Vol 29 (7) ◽  
pp. 541-547 ◽  
Author(s):  
Ming-Lu Xu ◽  
Dong-Cheol Moon ◽  
Chong-Soon Lee ◽  
Mi-Hee Woo ◽  
Eung Seok Lee ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Dna Topoisomerase

Nanocurcumin: a novel antifilarial agent with DNA topoisomerase II inhibitory activity

2014 ◽  
Vol 22 (5) ◽  
pp. 395-407 ◽  
Author(s):  
Mohammad Ali ◽  
Mohammad Afzal ◽  
Sekh Abdul Nasim ◽  
Istaq Ahmad
Keyword(s):  
Inhibitory Activity ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase

Antitumor and DNA Topoisomerase Ⅱα Inhibitory Activity of 6-Substituted-aryl-2-methoxyquinolines

2018 ◽  
Vol 38 (12) ◽  
pp. 3204 ◽  
Author(s):  
Zhiying Li ◽  
Yanjiao Ding ◽  
Huagang Bu ◽  
Yuemao Shen
Keyword(s):  
Inhibitory Activity ◽  
Dna Topoisomerase

ChemInform Abstract: TAN-1496 A, C and E, Diketopiperazine Antibiotics with Inhibitory Activity Against Mammalian DNA Topoisomerase I.

ChemInform ◽  
2010 ◽  
Vol 26 (20) ◽  
pp. no-no
Author(s):  
Y. FUNABASHI ◽  
T. HORIGUCHI ◽  
S. IINUMA ◽  
S. TANIDA ◽  
S. HARADA
Keyword(s):  
Inhibitory Activity ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase
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