carthamus tinctorius
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Foods ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 142
Author(s):  
Meitong He ◽  
Jihyun Kim ◽  
Chanhum Park ◽  
Eunju Cho

Deposition of amyloid-beta (Aβ) in the aging brain has been often observed and is thought to be a pathological feature of Alzheimer’s disease. The use of natural products for disease prevention and treatment is gaining attention worldwide. Carthamus tinctorius L. seed and Taraxacum coreanum have been used as traditional medicines in Asian countries, where they have been reported to exert anti-inflammatory and anti-oxidative effects. It has been demonstrated that the combination of C. tinctorius L. seed and T. coreanum has an effect on cognitive enhancement, indicating a ratio of 5:5 synergistically enhancing learning and memory abilities in comparison with a single treatment. Here, we aimed to investigate the protective effect of C. tinctorius L. seed and T. coreanum mixture (CT) at different concentrations on cognition in Aβ25-35-infused mice. CT-administered mice showed significant cognitive improvement in the T-maze, novel object recognition, and Morris water maze tests. Moreover, amyloidogenesis-related proteins, such as β-secretase and γ-secretase, were detected and their protein levels decreased after treatment with CT. Our study shows that CT attenuates cognitive dysfunction by improving learning and memory capability and regulating Aβ-related proteins in Aβ25-35-injected mice. These findings suggest that CT might be a candidate for functional food on cognitive improvement.


Author(s):  
K. V. Mustyatse ◽  
N. S. Chavdar ◽  
O. M. Zagorodnyaya

Carthamus tinctorius L. is a plant, that is used for oil production and dyeing, and also used for medical purposes and cosmetology. A distinctive biological feature of this plant is its high drought resistance. In the process of global warming the increase in air temperature in Transnistria over the past 70 years amounted to 1,2…1,3 °C, the increase in soil temperature over the past 20 years in the observed soil layer 0,2…3,2 m amounted 0,8…1,2 °C. In this regard the intercalation of drought resistant crops, such as Carthamus tinctorius L., into agricultural production is relevant. The dura- tion of the growing season of a Carthamus tinctorius L. collection specimen of unknown origin in the Republican Botanical Garden (in the town of Tiraspol) when sown in middle of April for the period from the year of 2008 to the year of 2017 ranged from 103 to 113 days. In the conditions of Transnistria in the year of 2020 for the first time the influence of sowing time of Carthamus tinctorius L. on the development of a complex of features was studied. Sowing of Carthamus tinctorius was carried out five times: the 20th and the 27th of March, the 3rd and the 14th of April, the 2nd of May. The study of the influence of the sowing time showed decreasing values of the complex of features with later sowing time of Carthamus tinctorius L. The mostly significant decreased with a later sowing time were such features as the number of branches of the first and the second level, the number of seeds in the inflorescence, the number of seeds per plant. The best sowing date in the conditions of an acute drought in the year of 2020 was the first sowing time on the 20th of March. The value of the features in this sowing period was: plants’ height — 55 cm, the number of branches of the first level — 8,7 pieces, the number of branches of the second level — 4,6 pieces, the number of inflorescences per plant — 14,1 pieces, the number of seeds in the inflorescence — 7,0 pieces, the number of seeds per plant — 64,8 pieces.


2021 ◽  
Author(s):  
Yi Li ◽  
Xiaotian Liu ◽  
Peilin Zhang ◽  
Yuchen Li ◽  
Mengru Sun ◽  
...  

Abstract Background: Zonula occludens-1 (ZO-1) protein ensures cerebrovascular integrity against brain ischemic injury. Hydroxysafflor yellow A (HSYA) is a major ingredient of safflower (Carthamus tinctorius L.) with anti-oxidative activity. Because conventional ROS scavengers display poor reactivity with endogenous ROS, this study investigated whether HSYA protected ZO-1 by targeting the enzymes responsible for ROS generation.Methords: Photothrombotic stroke model was prepared in mice to evaluate the protective effect of HSYA on cerebrovascular endothelium. The molecular regulation was investigated in cultured cerebral microvascular endothelial cells (bEnd.3 cells).Results: Oral administration of HSYA (50 mg/kg) reduced cerebral vascular leakage with ZO-1 protection in mice after stroke, largely due to suppression of ROS-associated inflammation. In LPS-stimulated bEnd.3 cells, HSYA increased the ratio of NAD+/NADH to restore Sirt1 induction, which bound to Von Hippel-Lindau (VHL) to ensure HIF-1α protein degradation. Although both NOX1 and NOX2 isoforms were inducible in endothelial cells, we identified NOX2 as the driving force of ROS production. Chromatin immunoprecipitation and luciferase report gene assay revealed that HIF-1α transcriptionally regulated p47phox and Nox2 subunits for the assembly of NOX2 complex, which was blocked by HSYA treatment, largely by reducing HIF-1α accumulation. Inflammation-associated lipid peroxidation impaired ZO-1 protein, but HSYA treatment attenuated carbonyl modification and thus prevented ZO-1 protein from 20S proteasome-mediated degradation, eventually protecting endothelial integrity. In microvascular ZO-1 deficient mice, we further confirmed that HSYA protected cerebrovascular integrity and attenuated ischemic injury dependent on ZO-1 protection. Conclusions: HSYA blocked HIF-1α/NOX2 signaling cascades to protect ZO-1 from proteasomal degradation, suggesting that targeting NOX2 in endothelium is a potential therapeutic strategy to protect against ischemic brain injury.


2021 ◽  
Vol 49 (4) ◽  
pp. 12605
Author(s):  
Radu E. SESTRAS

The papers published in Notulae Botanicae Horti Agrobotanici Cluj-Napoca, Issue 4, Volume 49, 2021 represent new exciting researches in different topics of life science, respectively in plant science, horticulture, agronomy and crop science. Among the interesting articles we invite you to find news about: Cotton versus climate change: the case of Greek cotton production; Agronomic and genetic approaches for enhancing tolerance to heat stress in rice; Insights on solanaceous resistance against tomato leafminer (Tuta absoluta), with emphasis on chemical compounds useful in integrated pest management; Role of conventional and molecular techniques in soybean yield and quality improvement - A critical review; Assessment of cold stress tolerance in maize through quantitative trait locus, genome-wide association study and transcriptome analysis; Beneficial microorganisms enhance the growth of basil (Ocimum basilicum L.) under greenhouse conditions; Genome-wide identification and expression profiling of duplicated flavonoid 3'-hydroxylase gene family in Carthamus tinctorius L.; Comparative analysis of genetic diversity in Norway spruce (Picea abies) clonal seed orchards and seed stands, etc.


Plants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2795
Author(s):  
Yun Jung Lee ◽  
Yong Pyo Lee ◽  
Chang Seob Seo ◽  
Eun Sik Choi ◽  
Byung Hyuk Han ◽  
...  

Carthamus tinctorius L., known as safflower, has been used in traditional treatment for cardiovascular, cerebrovascular, and diabetic vascular complications. We proposed to investigate how the ethanol extract of Carthamus tinctorius L. (ECT) can be used ethnopharmacologically and alleviate vascular inflammatory processes under cytokine stimulation in human vascular endothelial cells. Using the optimized HPLC method, six markers were simultaneously analyzed for quality control of ECT. Pretreatment with ECT (10–100 μg/mL) significantly reduced the increase of leukocyte adhesion to HUVEC by TNF-α in a dose-dependent manner. Cell adhesion molecules (CAMs) such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial cell selectin (E-selectin) are decreased by ECT. In addition, ECT significantly suppressed TNF-α-induced oxidative stress referring to reactive oxygen species (ROS) production. p65 NF-κB nuclear translocation and its activation were inhibited by ECT. Furthermore, pretreatment of ECT increased the HO-1 expression, and nuclear translocation of Nrf-2. These data suggest the potential role of ECT as a beneficial therapeutic herb in vascular inflammation via ROS/NF-kB pathway and the regulation of Nrf-2/HO-1 signaling axis is involved in its vascular protection. Thus, further study will be needed to clarify which compound is dominant for protection of vascular diseases.


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