Tandem Nucleophilic Reaction Leading to Hydrofurans: Application to One-Pot Synthesis of Antitumor Naphthofuran Natural Product

Heterocycles ◽  
1999 ◽  
Vol 51 (3) ◽  
pp. 497 ◽  
Author(s):  
Hisahiro Hagiwara ◽  
Kouji Sato ◽  
Toshio Suzuki ◽  
Masayoshi Ando
Keyword(s):  
Natural Product ◽  
Nucleophilic Reaction ◽  
One Pot ◽  
One Pot Synthesis

One-pot synthesis of natural-product inspired spiroindolines with anti-cancer activities

2022 ◽  
Author(s):  
Shiqiang Li ◽  
Wei Yan ◽  
Liu-Jun He ◽  
Ming Zhang ◽  
Dianyong Tang ◽  
...  
Keyword(s):  
Natural Product ◽  
Cascade Reaction ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Anti Cancer

A post-Ugi/diastereoselective cascade reaction was developed to construct naturally existing spiroindolines via a facile and metal-free one-pot protocol. During the construction, a new C-C bond was formed through a selective...

scholarly journals One-pot synthesis of tetracyclic fused imidazo[1,2-a]pyridines via a three-component reaction

2016 ◽  
Vol 12 ◽  
pp. 1487-1492 ◽  
Author(s):  
Bo Yang ◽  
Chuanye Tao ◽  
Taofeng Shao ◽  
Jianxian Gong ◽  
Chao Che
Keyword(s):  
Functional Group ◽  
Nucleophilic Reaction ◽  
One Pot ◽  
Ene Reaction ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
Three Component Coupling

A novel three-component reaction has been developed to assemble biologically and pharmaceutically important tetracyclic fused imidazo[1,2-a]pyridines in a one-pot fashion utilizing readily available 2-aminopyridines, isatins and isocyanides. The three-component coupling proceeds through the Groebke–Blackburn–Bienaymé reaction followed by a retro-aza-ene reaction and subsequent nucleophilic reaction of the in-situ generated imidazo[1,2-a]pyridines bearing an isocyanate functional group.

scholarly journals Facile, Protection-Free, One-Pot Synthesis of Aureusidin

2014 ◽  
Vol 9 (11) ◽  
pp. 1934578X1400901
Author(s):  
Quoc Vuong Nguyen ◽  
Phuong Diep Thi Lan ◽  
Hang Pham Thi ◽  
Van Chien Vu ◽  
Tuan Nguyen Le ◽  
...  
Keyword(s):  
Natural Product ◽  
High Purity ◽  
Good Yield ◽  
Synthetic Approach ◽  
One Pot ◽  
Simple Route ◽  
One Pot Synthesis ◽  
Bioactive Natural Product ◽  
Vegetal Species

A new, reliable, and convenient protection-free one-pot method for the synthesis of aureusidin (1) is described. The present synthetic approach involves the condensation of 4,6-dihydroxybenzofuranone with 3,4-dihydroxybenzaldehyde in the presence of concentrated HCl to afford aureusidin (1) in good yield with high purity. This procedure offers a short and simple route for the preparation of aureusidin (1), a bioactive natural product from several vegetal species, as well as for synthesis of other aurones.

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