An Asymmetric Reduction of Prochiral Ketones with a Chiral Hydride Reagent Prepared from Lithium Aluminium Hydride and (S)-2-(2,6-Xylidinomethyl)pyrrolidine

Heterocycles ◽  
1979 ◽  
Vol 12 (4) ◽  
pp. 499 ◽  
Author(s):  
Teruaki Mukaiyama ◽  
Masatoshi Asami
Keyword(s):  
Asymmetric Reduction ◽  
Lithium Aluminium Hydride ◽  
Lithium Aluminium ◽  
Prochiral Ketones

ASYMMETRIC REDUCTION OF ACETOPHENONE WITH CHIRAL HYDRIDE REAGENT PREPARED FROM LITHIUM ALUMINIUM HYDRIDE AND (S)-2-(ANILINOMETHYL)PYRROLIDINE

1977 ◽  
Vol 6 (7) ◽  
pp. 783-786 ◽  
Author(s):  
Teruaki Mukaiyama ◽  
Masatoshi Asami ◽  
Jun-ichi Hanna ◽  
Susumu Kobayashi
Keyword(s):  
Asymmetric Reduction ◽  
Lithium Aluminium Hydride ◽  
Lithium Aluminium

Asymmetric reduction of p-alkylacetophenones

1986 ◽  
Vol 51 (3) ◽  
pp. 684-686 ◽  
Author(s):  
Otakar Červinka ◽  
Anna Fábryová ◽  
Ivana Brožová ◽  
Miroslav Holík
Keyword(s):  
Asymmetric Reduction ◽  
Optically Active ◽  
Lithium Aluminium Hydride ◽  
Lithium Aluminium

Asymmetric reduction of p-alkylacetophenones Ia-VIIa with lithium aluminium hydride in the presence of (-)-quinine affords optically active alcohols Ib-VIIb of the (R)-(+) configuration in optical yields of about 50%.

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