scholarly journals Antihypertensive effect of a calcium entry blocker as related to age - Double-blind trial using diltiazem.

1985 ◽  
Vol 16 (3) ◽  
pp. 577-588 ◽  
Author(s):  
Kizuku URAMOTO ◽  
Tsutomu WATANABE ◽  
Masao IKEDA
Keyword(s):  
Antihypertensive Effect ◽  
Calcium Entry ◽  
Calcium Entry Blocker ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
Entry Blocker

Flunarizine in the treatment of vertigo

1983 ◽  
Vol 97 (8) ◽  
pp. 697-704 ◽  
Author(s):  
L. Wouters ◽  
W. Amery ◽  
G. Towse
Keyword(s):  
Clinical Efficacy ◽  
Dose Schedule ◽  
Calcium Entry ◽  
Controlled Trials ◽  
Calcium Entry Blocker ◽  
Loading Dose ◽  
Rapid Improvement ◽  
Double Blind ◽  
Entry Blocker ◽  
Pharmacological Studies

AbstractExperience with flunarizine, a selective calcium-entry blocker, in the treatment of dizziness is reviewed. Clinical efficacy was predicted in pharmacological studies both in rabbits and humans: torsion swing or caloric induced nystagmus were significantly suppressed by flunarizine. Open therapeutic findings, using clinical and electronystagmographic or audiographic assessments as well, showed that flunarizine is of benefit to patients with vertigo of labyrinthine as well as of cerebrovascular origin. These results were confirmed in double-blind controlled trials. Flunarizine, either started with a loading dose gradually decreased thereafter, or given at a fixed 10 mg. dose schedule was proven to produce rapid improvement of dizziness and unsteadiness and to be tolerated very well.

Migraine Treatment With Nicardipine

Cephalalgia ◽  
1990 ◽  
Vol 10 (3) ◽  
pp. 111-116 ◽  
Author(s):  
Massimo Leandri ◽  
Sergio Rigardo ◽  
Rodolfo Schizzi ◽  
Carlo Italo Parodi
Keyword(s):  
Side Effects ◽  
Detailed Analysis ◽  
Migraine Without Aura ◽  
Calcium Entry ◽  
Migraine Treatment ◽  
Calcium Entry Blocker ◽  
Double Blind ◽  
Mean Intensity ◽  
Entry Blocker ◽  
The Cross

A novel calcium entry blocker, nicardipine, has been tested using a dosage of 20 mg twice a day against placebo on 30 patients suffering from migraine without aura, according to a double-blind, cross-over design; overall duration of the study was four months (two with nicardipine and two with placebo). Migraine parameters such as monthly frequency, mean intensity and mean duration of attacks were monitored. Two indexes were also calculated: index A (monthly frequency x mean intensity) and index B (monthly frequency x mean intensity x mean duration). All the parameters considered and the two indexes showed a marked and significant improvement after nicardipine treatment in comparison to both placebo and pre-study scores. Detailed analysis of the cross-over results showed that improvement obtained with nicardipine lasted some time after the drug was discontinued. Nicardipine did not alter the blood and attention tests performed and caused few side effects.

scholarly journals Antihypertensive effect of AJ-2615, a novel calcium entry blocker, in experimental hypertensive rats and dogs

1989 ◽  
Vol 49 ◽  
pp. 211
Author(s):  
Kunihiko Takeyama ◽  
Akihisa Ikeno ◽  
Hisao Minato ◽  
Buichi Fujitani ◽  
Katsuyoshi Nakatsuji ◽  
...  
Keyword(s):  
Antihypertensive Effect ◽  
Calcium Entry ◽  
Calcium Entry Blocker ◽  
Hypertensive Rats ◽  
Entry Blocker

99: Prulifloxacin Versus Levofloxacin in the Treatment of Chronic Bacterial Prostatitis: A Prospective, Randomized, Double-Blind Trial

2007 ◽  
Vol 177 (4S) ◽  
pp. 35-35
Author(s):  
Gianluca Giannarini ◽  
Andrea Mogorovich ◽  
Girolamo Morelli ◽  
Maurizio De Maria ◽  
Francesca Manassero ◽  
...  
Keyword(s):  
Double Blind Trial ◽  
Chronic Bacterial Prostatitis ◽  
Double Blind ◽  
Blind Trial ◽  
Bacterial Prostatitis
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