Synthesis of (R)-2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl 4-Methylbenzenesulfonate
2014 ◽
Vol 881-883
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pp. 465-468
Venlafaxine (Figure 1) is the new generation antidepressant drug. A synthetic route to the asymmetric synthesis of (R)-venlafaxine through Evans Aldol protocol was designed. The key intermediate, (R)-2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl) ethyl4-methylbenzenesulfonate was prepared from cyclohexanone.
1992 ◽
Vol 33
(24)
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pp. 3487-3490
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1999 ◽
Vol 40
(26)
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pp. 4861-4862
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2011 ◽
Vol 17
(17)
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pp. 4905-4913
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2002 ◽
Vol 13
(4)
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pp. 429-435
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