Adult respiratory distress syndrome: a consideration with rapid respiratory decompensation in association with preeclampsia

Adult respiratory distress syndrome, presenting as rapid respiratory decompensation in the setting of preeclampsia at 36 weeks of gestation, was managed by early hemodynamic monitoring with pulmonary artery catheterization. With confirmation of the diagnosis of preeclampsia the patient was delivered promptly; improvement of her respiratory failure was observed within 48 hours. Consideration of adult respiratory distress syndrome in the setting of preeclampsia is discussed, with emphasis on early confirmation of the diagnosis and determination of the precise mechanisms of pulmonary edema.

Download Full-text

Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome

Inflammation ◽

10.1007/bf00918976 ◽

1992 ◽

Vol 16 (5) ◽

pp. 509-517 ◽

Cited By ~ 22

Author(s):

Roger F. Espiritu ◽

Jean -Francois Pittet ◽

Michael A. Matthay ◽

Edward J. Goetzl

Keyword(s):

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Pulmonary Edema ◽

Adult Respiratory Distress Syndrome ◽

Distress Syndrome ◽

Edema Fluid

Download Full-text

APPROACH TO ADULT RESPIRATORY DISTRESS SYNDROME AND RESPIRATORY FAILURE IN ELDERLY PATIENTS

Clinics in Chest Medicine ◽

10.1016/s0272-5231(21)00916-3 ◽

1993 ◽

Vol 14 (3) ◽

pp. 571-582

Author(s):

David Griffith ◽

Steven Idell

Keyword(s):

Respiratory Failure ◽

Elderly Patients ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Adult Respiratory Distress Syndrome ◽

Distress Syndrome

Download Full-text

Response of cultured human pulmonary artery endothelial cells to endotoxin

AJP Lung Cellular and Molecular Physiology ◽

10.1152/ajplung.1995.268.2.l239 ◽

1995 ◽

Vol 268 (2) ◽

pp. L239-L244 ◽

Cited By ~ 2

Author(s):

B. Meyrick ◽

L. C. Berry ◽

B. W. Christman

Keyword(s):

Endothelial Cells ◽

Lactate Dehydrogenase ◽

Pulmonary Artery ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Prostaglandin E2 ◽

Adult Respiratory Distress Syndrome ◽

Distress Syndrome ◽

Human Pulmonary Artery

Endotoxemia is the leading cause of the adult respiratory distress syndrome. The effects of endotoxin on pulmonary endothelium, both in vivo and in culture, are diverse and complicated, and vary between species and cellular origin. Species such as sheep and cows are particularly sensitive to endotoxin, whereas rats and mice are more resistant. Studies using cultured pulmonary endothelial cells confirm these findings. Such species variations lead us to question whether human pulmonary artery endothelial cells (HPAEC) are directly affected by endotoxin. The present study examined the effects of endotoxin on HPAEC. Cells were exposed to endotoxin (0.001-10 micrograms/ml) for 24 h and were examined by phase-contrast microscopy, and measurements were made of lactate dehydrogenase, prostacyclin, and prostaglandin E2 release in the cell-free supernatant. In the presence of serum, endotoxin doses as small as 0.01 microgram/ml resulted in endothelial retraction and pyknosis compared with controls (P < 0.05). Exposure to 10 micrograms/ml of endotoxin resulted in a significant increase in the number of pyknotic cells (P < 0.05), and lactate dehydrogenase release paralleled this finding. Endotoxin also resulted in a gradual increase in prostaglandin E2 release, reaching significance at 1 and 10 micrograms/ml of endotoxin (P < 0.05). A similar trend was noted for prostacyclin release. We conclude that the direct cytotoxic effects elicited by endotoxin on HPAEC may contribute to the onset of pulmonary edema in patients with adult respiratory distress syndrome.

Download Full-text