scholarly journals Intraoral Mucoepidermoid Carcinoma of Salivary Glands: Lack of Association Among Clinicopathological Features and Immunoexpression of c-erbB-2 in 29 Cases

Author(s):  
Vanessa Fátima Bernardes ◽  
Maria Letícia Ramos-Jorge ◽  
Maria Auxiliadora Vieira Carmo ◽  
Sérgio Vitorino Cardoso ◽  
Ricardo Alves Mesquita ◽  
...  
2012 ◽  
Vol 27 (4) ◽  
pp. 381-388 ◽  
Author(s):  
Mark R. Darling ◽  
Nelly N. Hashem ◽  
Irene Zhang ◽  
Mohamed Mohamed ◽  
Kevin Fung ◽  
...  

Objectives Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands. Materials and methods: A standard immunoperoxidase staining technique was used to assess the Immunoexpression profile of KLK10 in normal salivary glands and 3 types of salivary gland tumour: pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. Results Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Neither of the malignant tumours (adenoid cystic carcinoma and mucoepidermoid carcinoma) showed a significant alteration in the immunoreactive scores of KLK10 in comparison with the normal salivary gland tissues. KLK10 immunoreactive scores were comparable in adenoid cystic carcinoma and mucoepidermoid carcinoma. Pleomorphic adenoma had significantly lower levels of KLK10 than mucoepidermoid carcinoma. Conclusions The finding of lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours.


2016 ◽  
Vol 13 (2) ◽  
pp. 286-295
Author(s):  
Mohamed R. Elshafey ◽  
Mohamed R. Elshafey ◽  
Rehab A. Ahmed ◽  
Mohamed I Mourad ◽  
Essam T. Gaballah ◽  
...  

2016 ◽  
Vol 77 (04) ◽  
pp. e156-e159 ◽  
Author(s):  
Rimal Dossani ◽  
Hesam Akbarian-Tefaghi ◽  
Lori Lemonnier ◽  
Vikas Mehta ◽  
Jamie Jacobsohn ◽  
...  

Author(s):  
Laurie Saloner Dahan ◽  
Roch Giorgi ◽  
Sébastien Vergez ◽  
Ludovic Le Taillandier de Gabory ◽  
Valérie Costes-Martineau ◽  
...  

1996 ◽  
Vol 122 (3) ◽  
pp. 177-180 ◽  
Author(s):  
K. Plambeck ◽  
R. E. Friedrich ◽  
D. Hellner ◽  
K. Donath ◽  
R. Schmelzle

2011 ◽  
Author(s):  
Frederico O. Gleber-Netto ◽  
Taynara Nunes Guedes Florencio ◽  
Silvia Ferreira Sousa ◽  
Elismauro Francisco Mendonça ◽  
Carolina Cavalieri Gomes ◽  
...  

Author(s):  
RAPHAELLA DE OLIVEIRA PINTO CALDAS ◽  
LUANA D´ARC DIAFILOS TEIXEIRA ◽  
PAULINA SCHMIDT BOESEL ◽  
ANA CAROLINE DE AGUIAR BRUNO ◽  
JOSÉ ALEXANDRE DA ROCHA CURVELO ◽  
...  

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